Scientific
MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis
These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.
Affected Genes

Navigation/Query Panel:
Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].
Regulation description Gene Ontology Ratio Class Gene Accession Maximum Ratio Minimum Ratio
Results: HTML CSV LaTeX
Showing element 1 to 50 of 91 in total
Gene Ontology: nucleus
Class: cellular component

\def\wcA{0.25\textwidth}
\def\wcB{0.25\textwidth}
\def\wcC{0.25\textwidth}
\begin{longtable}{|c|c|c|}
\hline
\parbox{\wcA}{\vspace{3pt}\noindent
Regulation\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent
description\vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent
Ratio\vspace{3pt}}\\
\hline
\hline
\multirow{39}{*}{\parbox{\wcA}{\vspace{3pt}\noindent
down\vspace{3pt}}}&\parbox{\wcB}{\vspace{3pt}\noindent
Antigen KI-67. \vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent
1.73211\vspace{3pt}}\\\cline{2-3}
&\parbox{\wcB}{\vspace{3pt}\noindent
AT-hook-containing transcription factor 1 (Embryonic large molecule derived from yolk sac). \vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent
3.83977\vspace{3pt}}\\\cline{2-3}
&\parbox{\wcB}{\vspace{3pt}\noindent
Calsenilin (Kv channel-interacting protein 3) (KChIP3) (A-type potassium channel modulatory protein 3) (DRE-antagonist modulator) (DREAM). \vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent
3.27919\vspace{3pt}}\\\cline{2-3}
&\parbox{\wcB}{\vspace{3pt}\noindent
CCR4-NOT transcription complex subunit 2 (CCR4-associated factor 2). \vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent
1.30082\vspace{3pt}}\\\cline{2-3}
&\parbox{\wcB}{\vspace{3pt}\noindent
Chromodomain-helicase-DNA-binding protein 6 (EC 3.6.1.-) (ATP- dependent helicase CHD6) (CHD-6) (Radiation-induced gene B protein). \vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent
1.60746\vspace{3pt}}\\\cline{2-3}
&\parbox{\wcB}{\vspace{3pt}\noindent
Disco-interacting protein 2 homolog C. \vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent
1.21384\vspace{3pt}}\\\cline{2-3}
&\parbox{\wcB}{\vspace{3pt}\noindent
DNA-directed RNA polymerase III subunit RPC8 (RNA polymerase III subunit C8) (DNA-directed RNA polymerase III subunit H) (DNA-directed RNA polymerase III subunit 22.9 kDa polypeptide). \vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent
6.56408\vspace{3pt}}\\\cline{2-3}
&\parbox{\wcB}{\vspace{3pt}\noindent
E3 ubiquitin-protein ligase CHFR (EC 6.3.2.-) (Checkpoint with forkhead and RING finger domains protein) (RING finger protein 196). \vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent
1.30869\vspace{3pt}}\\\cline{2-3}
&\parbox{\wcB}{\vspace{3pt}\noindent
Enhancer of polycomb homolog 1. \vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent
4.49282\vspace{3pt}}\\\cline{2-3}
&\parbox{\wcB}{\vspace{3pt}\noindent
Exosome complex exonuclease RRP44 (EC 3.1.13.-) (Ribosomal RNA- processing protein 44) (DIS3 protein homolog). \vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent
1.683\vspace{3pt}}\\\cline{2-3}
&\parbox{\wcB}{\vspace{3pt}\noindent
Hematological and neurological expressed 1 protein (Androgen-regulated protein 2). \vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent
3.62109\vspace{3pt}}\\\cline{2-3}
&\parbox{\wcB}{\vspace{3pt}\noindent
Homeobox protein Hox-D3 (Hox-4A). \vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent
1.27461\vspace{3pt}}\\\cline{2-3}
&\parbox{\wcB}{\vspace{3pt}\noindent
Homeobox protein TGIF2 (5'-TG-3'-interacting factor 2) (TGFB-induced factor 2) (TGF(beta)-induced transcription factor 2). \vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent
3.48313\vspace{3pt}}\\\cline{2-3}
&\parbox{\wcB}{\vspace{3pt}\noindent
Melanoma-associated antigen C2 (MAGE-C2 antigen) (MAGE-E1 antigen) (Hepatocellular carcinoma-associated antigen 587) (Cancer-testis antigen 10) (CT10). \vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent
1.29952\vspace{3pt}}\\\cline{2-3}
&\parbox{\wcB}{\vspace{3pt}\noindent
Myelin transcription factor 1-like protein (MyT1L protein) (MyT1-L). \vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent
2.58329\vspace{3pt}}\\\cline{2-3}
&\parbox{\wcB}{\vspace{3pt}\noindent
Nuclear factor of activated T-cells, cytoplasmic 3 (NF-ATc3) (NFATc3) (T cell transcription factor NFAT4) (NF-AT4) (NFATx). \vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent
5.32612\vspace{3pt}}\\\cline{2-3}
&\parbox{\wcB}{\vspace{3pt}\noindent
Nuclear pore complex protein Nup153 (Nucleoporin Nup153) (153 kDa nucleoporin). \vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent
1.48389\vspace{3pt}}\\\cline{2-3}
&\parbox{\wcB}{\vspace{3pt}\noindent
Nuclear receptor ROR-alpha (Retinoid-related orphan receptor-alpha) (Nuclear receptor RZR-alpha). \vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent
1.98137\vspace{3pt}}\\\cline{2-3}
&\parbox{\wcB}{\vspace{3pt}\noindent
Nucleolar preribosomal-associated protein 1 (Fragment). \vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent
1.36755\vspace{3pt}}\\\cline{2-3}
&\parbox{\wcB}{\vspace{3pt}\noindent
Nucleoplasmin-2. \vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent
5.83544\vspace{3pt}}\\\cline{2-3}
&\parbox{\wcB}{\vspace{3pt}\noindent
Pre-mRNA-splicing factor SYF2 (CCNDBP1-interactor) (p29). \vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent
3.43019\vspace{3pt}}\\\cline{2-3}
&\parbox{\wcB}{\vspace{3pt}\noindent
Prostaglandin G/H synthase 2 precursor (EC 1.14.99.1) (Cyclooxygenase- 2) (COX-2) (Prostaglandin-endoperoxide synthase 2) (Prostaglandin H2 synthase 2) (PGH synthase 2) (PGHS-2) (PHS II). \vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent
1.18096\vspace{3pt}}\\\cline{2-3}
&\parbox{\wcB}{\vspace{3pt}\noindent
Protein CWC15 homolog. \vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent
1.25205\vspace{3pt}}\\\cline{2-3}
&\parbox{\wcB}{\vspace{3pt}\noindent
Protein Jade-1 (PHD finger protein 17). \vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent
6.3909\vspace{3pt}}\\\cline{2-3}
&\parbox{\wcB}{\vspace{3pt}\noindent
Protein pelota homolog. \vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent
3.71868\vspace{3pt}}\\\cline{2-3}
&\parbox{\wcB}{\vspace{3pt}\noindent
Putative DNA helicase INO80 complex homolog 1 (EC 3.6.1.-) (hINO80). \vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent
1.81557\vspace{3pt}}\\\cline{2-3}
&\parbox{\wcB}{\vspace{3pt}\noindent
Ribonuclease P protein subunit p29 (EC 3.1.26.5) (hPOP4). \vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent
2.12709\vspace{3pt}}\\\cline{2-3}
&\parbox{\wcB}{\vspace{3pt}\noindent
Selenocysteine-specific elongation factor (Elongation factor sec) (Eukaryotic elongation factor, selenocysteine-tRNA-specific). \vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent
1.65835\vspace{3pt}}\\\cline{2-3}
&\parbox{\wcB}{\vspace{3pt}\noindent
Serine/threonine-protein kinase VRK3 (EC 2.7.11.1) (Vaccinia-related kinase 3). \vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent
4.14557\vspace{3pt}}\\\cline{2-3}
&\parbox{\wcB}{\vspace{3pt}\noindent
SERTA domain-containing protein 3 (Replication protein-binding trans- activator) (RPA-binding trans-activator). \vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent
2.83611\vspace{3pt}}\\\cline{2-3}
&\parbox{\wcB}{\vspace{3pt}\noindent
Speedy protein A (Speedy-1) (Spy1) (Rapid inducer of G2/M progression in oocytes A) (RINGO A) (hSpy/Ringo A). \vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent
1.27696\vspace{3pt}}\\\cline{2-3}
&\parbox{\wcB}{\vspace{3pt}\noindent
T-box transcription factor TBX2 (T-box protein 2). \vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent
1.28356\vspace{3pt}}\\\cline{2-3}
&\parbox{\wcB}{\vspace{3pt}\noindent
Transcription factor GATA-6 (GATA-binding factor 6). \vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent
3.29064\vspace{3pt}}\\\cline{2-3}
&\parbox{\wcB}{\vspace{3pt}\noindent
Wee1-like protein kinase (EC 2.7.10.2) (Wee1A kinase) (WEE1hu). \vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent
1.48363\vspace{3pt}}\\\cline{2-3}
&\parbox{\wcB}{\vspace{3pt}\noindent
X box-binding protein 1 (XBP-1) (Tax-responsive element-binding protein 5). \vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent
4.4149\vspace{3pt}}\\\cline{2-3}
&\parbox{\wcB}{\vspace{3pt}\noindent
Zinc finger and SCAN domain-containing protein 4 (Zinc finger protein 494). \vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent
1.86204\vspace{3pt}}\\\cline{2-3}
&\parbox{\wcB}{\vspace{3pt}\noindent
Zinc finger protein 202 (Zinc finger protein with KRAB and SCAN domains 10). \vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent
1.89168\vspace{3pt}}\\\cline{2-3}
&\parbox{\wcB}{\vspace{3pt}\noindent
Zinc finger protein basonuclin-2. \vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent
1.1243\vspace{3pt}}\\\cline{2-3}
&\parbox{\wcB}{\vspace{3pt}\noindent
Zinc finger protein OZF (Only zinc finger protein) (Zinc finger protein 146). \vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent
1.25113\vspace{3pt}}\\\hline
\multirow{11}{*}{\parbox{\wcA}{\vspace{3pt}\noindent
up\vspace{3pt}}}&\parbox{\wcB}{\vspace{3pt}\noindent
Ataxin-7 (Spinocerebellar ataxia type 7 protein). \vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent
2.29381\vspace{3pt}}\\\cline{2-3}
&\parbox{\wcB}{\vspace{3pt}\noindent
Calcium/calmodulin-dependent protein kinase type 1B (EC 2.7.11.17) (CaM kinase IB) (CaM kinase I beta) (CaMKI-beta) (CaM-KI beta) (Pregnancy up-regulated non-ubiquitously expressed CaM kinase). \vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent
1.61673\vspace{3pt}}\\\cline{2-3}
&\parbox{\wcB}{\vspace{3pt}\noindent
Calpain-3 (EC 3.4.22.54) (Calpain L3) (Calpain p94) (Calcium-activated neutral proteinase 3) (CANP 3) (Muscle-specific calcium-activated neutral protease 3) (nCL-1). \vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent
2.87038\vspace{3pt}}\\\cline{2-3}
&\parbox{\wcB}{\vspace{3pt}\noindent
Centromere protein L (CENP-L) (Interphase centromere complex protein 33). \vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent
1.78708\vspace{3pt}}\\\cline{2-3}
&\parbox{\wcB}{\vspace{3pt}\noindent
Centromere protein S (CENP-S) (Apoptosis-inducing TAF9-like domain- containing protein 1). \vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent
2.7017\vspace{3pt}}\\\cline{2-3}
&\parbox{\wcB}{\vspace{3pt}\noindent
Chromodomain helicase-DNA-binding protein 4 (EC 3.6.1.-) (ATP- dependent helicase CHD4) (CHD-4) (Mi-2 autoantigen 218 kDa protein) (Mi2-beta). \vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent
1.78439\vspace{3pt}}\\\cline{2-3}
&\parbox{\wcB}{\vspace{3pt}\noindent
Chromodomain-helicase-DNA-binding protein 7 (EC 3.6.1.-) (ATP- dependent helicase CHD7) (CHD-7). \vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent
1.25808\vspace{3pt}}\\\cline{2-3}
&\parbox{\wcB}{\vspace{3pt}\noindent
Cisplatin resistance-associated overexpressed protein (cAMP regulatory element-associated protein 1) (CRE-associated protein 1) (CREAP-1) (Luc7A) (Okadaic acid-inducible phosphoprotein OA48-18). \vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent
2.91954\vspace{3pt}}\\\cline{2-3}
&\parbox{\wcB}{\vspace{3pt}\noindent
Cyclin-A2 (Cyclin-A). \vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent
1.45635\vspace{3pt}}\\\cline{2-3}
&\parbox{\wcB}{\vspace{3pt}\noindent
Cysteine desulfurase, mitochondrial precursor (EC 2.8.1.7). \vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent
1.19539\vspace{3pt}}\\\cline{2-3}
&\parbox{\wcB}{\vspace{3pt}\noindent
Forkhead box protein P2 (CAG repeat protein 44) (Trinucleotide repeat- containing gene 10 protein). \vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent
1.57088\vspace{3pt}}\\\hline
nd{longtable}

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.

 - The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells. 

 - The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component. 

 - The Gene Ontology terms as linked to the specific gene.

 - Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray

 - Accession is the GO accession key. 

 - Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.

 - Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- http://analysis.yellowcouch.org/