MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Class	Ratio	Regulation	Gene Ontology	description	Gene	Minimum Ratio	Accession	Maximum Ratio

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Showing element 101 to 150 of 2667 in total

Class  : biological process

Ratio	Regulation	Gene Ontology	description
1.19539	up	metabolic process	Cysteine desulfurase, mitochondrial precursor (EC 2.8.1.7). [Uniprot/SWISSPROT;Acc:Q9Y697]
		protein complex assembly
		sulfur amino acid metabolic process
1.19545		apoptosis	Deoxyribonuclease-2-alpha precursor (EC 3.1.22.1) (Deoxyribonuclease II alpha) (DNase II alpha) (Acid DNase) (Lysosomal DNase II) (R31240_2). [Uniprot/SWISSPROT;Acc:O00115]
		DNA catabolic process
		DNA metabolic process
		erythrocyte differentiation
		multicellular organismal development
1.20102		apoptosis	Metalloreductase STEAP3 (EC 1.16.1.-) (Six-transmembrane epithelial antigen of prostate 3) (Tumor suppressor-activated pathway protein 6) (hTSAP6) (pHyde) (hpHyde) (Dudulin-2). [Uniprot/SWISSPROT;Acc:Q658P3]
		cell cycle
		electron transport
		ion transport
		iron ion transport
1.20481	down	biological_process	Neurosecretory protein VGF precursor. [Uniprot/SWISSPROT;Acc:O15240]
		generation of precursor metabolites and energy
		ovarian follicle development
		sexual reproduction
1.20619		ATP hydrolysis coupled proton transport	Sodium/potassium-transporting ATPase subunit alpha-4 (EC 3.6.3.9) (Sodium pump subunit alpha-4) (Na(+)/K(+) ATPase alpha-4 subunit). [Uniprot/SWISSPROT;Acc:Q13733]
		cation transport
		hydrogen ion homeostasis
		metabolic process
		monovalent inorganic cation transport
		potassium ion transport
		proton transport
		sodium ion transport
		sperm motility
		transport
1.20924		alcohol metabolic process	Aldehyde dehydrogenase 1A3 (EC 1.2.1.5) (Aldehyde dehydrogenase 6) (Retinaldehyde dehydrogenase 3) (RALDH-3). [Uniprot/SWISSPROT;Acc:P47895]
		embryonic eye morphogenesis
		lipid metabolic process
		metabolic process
		nucleus accumbens development
		optic cup morphogenesis involved in camera-type eye development
		positive regulation of apoptosis
		retinoic acid metabolic process
1.21384		metabolic process	Disco-interacting protein 2 homolog C. [Uniprot/SWISSPROT;Acc:Q9Y2E4]
1.21657	up	cell cycle	Septin-5 (Peanut-like protein 1) (Cell division control-related protein 1) (CDCrel-1). [Uniprot/SWISSPROT;Acc:Q99719]
		cytokinesis
		positive regulation of exocytosis
		regulation of exocytosis
		small GTPase mediated signal transduction
		synaptic vesicle targeting
1.21698		electron transport	Kelch-like protein 34. [Uniprot/SWISSPROT;Acc:Q8N239]
		metabolic process
1.21705		cellular protein metabolic process	T-complex protein 1 subunit beta (TCP-1-beta) (CCT-beta). [Uniprot/SWISSPROT;Acc:P78371]
		protein amino acid phosphorylation
		protein folding
		regulation of progression through cell cycle
1.21871	down	apoptotic program	Bcl-2-interacting killer (Apoptosis inducer NBK) (BP4) (BIP1). [Uniprot/SWISSPROT;Acc:Q13323]
		induction of apoptosis

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.