MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	description	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 501 to 550 of 1031 in total

Class  : molecular function

Ratio	Regulation	description	Gene Ontology
1.59819	up	Serine/threonine-protein phosphatase with EF-hands 2 (EC 3.1.3.16) (PPEF-2). [Uniprot/SWISSPROT;Acc:O14830]	phosphoprotein phosphatase activity
			protein serine/threonine phosphatase activity
1.60668		Transient receptor potential cation channel subfamily V member 4 (TrpV4) (osm-9-like TRP channel 4) (OTRPC4) (Vanilloid receptor-like channel 2) (Vanilloid receptor-like protein 2) (VRL-2) (Vanilloid receptor-related osmotically-activated channel) (VR-OAC [Uniprot/SWISSPROT;Acc:Q9HBA0]	calcium channel activity
			calcium ion binding
			calmodulin binding
			identical protein binding
			ion channel activity
1.60746	down	Chromodomain-helicase-DNA-binding protein 6 (EC 3.6.1.-) (ATP- dependent helicase CHD6) (CHD-6) (Radiation-induced gene B protein). [Uniprot/SWISSPROT;Acc:Q8TD26]	ATP binding
			ATP-dependent helicase activity
			chromatin binding
			DNA binding
			helicase activity
			hydrolase activity
			nucleic acid binding
			nucleotide binding
			tetracycline:hydrogen antiporter activity
1.61347		Calmodulin-like protein 5 (Calmodulin-like skin protein). [Uniprot/SWISSPROT;Acc:Q9NZT1]	calcium ion binding
			protein binding
1.61673	up	Calcium/calmodulin-dependent protein kinase type 1B (EC 2.7.11.17) (CaM kinase IB) (CaM kinase I beta) (CaMKI-beta) (CaM-KI beta) (Pregnancy up-regulated non-ubiquitously expressed CaM kinase). [Uniprot/SWISSPROT;Acc:Q6P2M8]	ATP binding
			calcium ion binding
			calmodulin binding
			nucleotide binding
			protein kinase activity
			protein serine/threonine kinase activity
			protein-tyrosine kinase activity
			transferase activity
1.61987		Proteinase-activated receptor 1 precursor (PAR-1) (Thrombin receptor) (Coagulation factor II receptor). [Uniprot/SWISSPROT;Acc:P25116]	G-protein coupled receptor activity
			purinergic nucleotide receptor activity, G-protein coupled
			receptor activity
			receptor binding
			rhodopsin-like receptor activity
			thrombin receptor activity
1.62157		EF-hand domain-containing family member B. [Uniprot/SWISSPROT;Acc:Q8N7U6]	calcium ion binding
1.62709		Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48) (His domain-containing protein tyrosine phosphatase) (HD-PTP) (Protein tyrosine phosphatase TD14) (PTP-TD14). [Uniprot/SWISSPROT;Acc:Q9H3S7]	hydrolase activity
			phosphoric monoester hydrolase activity
			protein tyrosine phosphatase activity
1.63639		Cysteine-rich hydrophobic domain 2 protein (BrX-like translocated in leukemia). [Uniprot/SWISSPROT;Acc:Q9UKJ5]	molecular_function
1.63713		Armadillo repeat-containing X-linked protein 3 (Protein ALEX3) (ARM protein lost in epithelial cancers on chromosome X 3). [Uniprot/SWISSPROT;Acc:Q9UH62]	binding
1.6384		Olfactory receptor 6S1. [Uniprot/SWISSPROT;Acc:Q8NH40]	olfactory receptor activity
			receptor activity
			rhodopsin-like receptor activity
1.63945		Mitogen-activated protein kinase 4 (EC 2.7.11.24) (Extracellular signal-regulated kinase 4) (ERK-4) (MAP kinase isoform p63) (p63- MAPK). [Uniprot/SWISSPROT;Acc:P31152]	ATP binding
			MAP kinase activity
			nucleotide binding
			protein kinase activity
			protein serine/threonine kinase activity
			protein-tyrosine kinase activity
			transferase activity
1.65835	down	Selenocysteine-specific elongation factor (Elongation factor sec) (Eukaryotic elongation factor, selenocysteine-tRNA-specific). [Uniprot/SWISSPROT;Acc:P57772]	GTP binding
			GTPase activity

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.