MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	description	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 501 to 550 of 948 in total

Class  : biological process

Ratio	Regulation	description	Gene Ontology
1.60668	up	Transient receptor potential cation channel subfamily V member 4 (TrpV4) (osm-9-like TRP channel 4) (OTRPC4) (Vanilloid receptor-like channel 2) (Vanilloid receptor-like protein 2) (VRL-2) (Vanilloid receptor-related osmotically-activated channel) (VR-OAC [Uniprot/SWISSPROT;Acc:Q9HBA0]	response to mechanical stimulus
1.60746	down	Chromodomain-helicase-DNA-binding protein 6 (EC 3.6.1.-) (ATP- dependent helicase CHD6) (CHD-6) (Radiation-induced gene B protein). [Uniprot/SWISSPROT;Acc:Q8TD26]	chromatin assembly or disassembly
			chromatin remodeling
			nervous system development
			nucleosome assembly
			regulation of transcription, DNA-dependent
			response to antibiotic
			tetracycline transport
			transcription
1.61347		Calmodulin-like protein 5 (Calmodulin-like skin protein). [Uniprot/SWISSPROT;Acc:Q9NZT1]	ciliary or flagellar motility
			epidermis development
			signal transduction
1.61673	up	Calcium/calmodulin-dependent protein kinase type 1B (EC 2.7.11.17) (CaM kinase IB) (CaM kinase I beta) (CaMKI-beta) (CaM-KI beta) (Pregnancy up-regulated non-ubiquitously expressed CaM kinase). [Uniprot/SWISSPROT;Acc:Q6P2M8]	protein amino acid phosphorylation
1.61987		Proteinase-activated receptor 1 precursor (PAR-1) (Thrombin receptor) (Coagulation factor II receptor). [Uniprot/SWISSPROT;Acc:P25116]	activation of MAPKK activity
			anatomical structure morphogenesis
			apoptosis
			blood coagulation
			caspase activation
			cell motility
			elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)
			establishment of synaptic specificity at neuromuscular junction
			G-protein coupled receptor protein signaling pathway
			multicellular organismal development
			negative regulation of neuron apoptosis
			positive regulation of calcium ion transport
			positive regulation of cell proliferation
			positive regulation of I-kappaB kinase/NF-kappaB cascade
			positive regulation of smooth muscle contraction
			positive regulation of vasoconstriction
			protein kinase C activation
			regulation of progression through cell cycle
			regulation of sensory perception of pain
			release of sequestered calcium ion into cytosol
			response to wounding
			signal transduction
			STAT protein nuclear translocation
			tyrosine phosphorylation of STAT protein
1.62709		Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48) (His domain-containing protein tyrosine phosphatase) (HD-PTP) (Protein tyrosine phosphatase TD14) (PTP-TD14). [Uniprot/SWISSPROT;Acc:Q9H3S7]	dephosphorylation
			protein amino acid dephosphorylation
1.63639		Cysteine-rich hydrophobic domain 2 protein (BrX-like translocated in leukemia). [Uniprot/SWISSPROT;Acc:Q9UKJ5]	biological_process
1.6384		Olfactory receptor 6S1. [Uniprot/SWISSPROT;Acc:Q8NH40]	G-protein coupled receptor protein signaling pathway
			signal transduction
1.63945		Mitogen-activated protein kinase 4 (EC 2.7.11.24) (Extracellular signal-regulated kinase 4) (ERK-4) (MAP kinase isoform p63) (p63- MAPK). [Uniprot/SWISSPROT;Acc:P31152]	cell cycle
			protein amino acid phosphorylation
1.65422		Uncharacterized protein C9orf117. [Uniprot/SPTREMBL;Acc:Q5JU67]	signal transduction
1.65835	down	Selenocysteine-specific elongation factor (Elongation factor sec) (Eukaryotic elongation factor, selenocysteine-tRNA-specific). [Uniprot/SWISSPROT;Acc:P57772]	selenocysteine incorporation
			translational elongation
1.66123	up	KRAB-A domain containing 1 (KRBA1), mRNA [RefSeq_dna;Acc:NM_032534]	G-protein coupled receptor protein signaling pathway
			regulation of transcription, DNA-dependent
1.66679		TCDD-inducible poly [ADP-ribose] polymerase (EC 2.4.2.30) (Poly [ADP- ribose] polymerase 7) (PARP-7). [Uniprot/SWISSPROT;Acc:Q7Z3E1]	protein amino acid ADP-ribosylation

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.