MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	description	Gene Ontology	Class	Accession	Gene	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1969 to 2018 of 2667 in total

Ratio	Regulation	description	Gene Ontology	Class
2.7017	up	Centromere protein S (CENP-S) (Apoptosis-inducing TAF9-like domain- containing protein 1). [Uniprot/SWISSPROT;Acc:Q8N2Z9]	neuropeptide hormone activity	molecular function
			nucleosome	cellular component
			nucleosome assembly	biological process
			nucleus	cellular component
			soluble fraction
			synaptic transmission	biological process
2.70687		Cartilage acidic protein 1 precursor (68 kDa chondrocyte-expressed protein) (CEP-68) (ASPIC). [Uniprot/SWISSPROT;Acc:Q9NQ79]	calcium ion binding	molecular function
			homoiothermy	biological process
			ice binding	molecular function
			intracellular	cellular component
			response to freezing	biological process
			ribosome	cellular component
			structural constituent of ribosome	molecular function
			translation	biological process
2.72371		Opa-interacting protein 5. [Uniprot/SWISSPROT;Acc:O43482]	Cajal body	cellular component
			cell communication	biological process
			cellular_component	cellular component
			chromatin
			chromocenter
			nucleus
			protein binding	molecular function
2.75048		SAC3 domain containing 1 [RefSeq_peptide;Acc:NP_037431]	centrosome	cellular component
			centrosome duplication	biological process
			spindle	cellular component
			spindle assembly	biological process
2.75351		Protein phosphatase 1 regulatory subunit 14B (Phospholipase C beta 3 neighbouring gene protein). [Uniprot/SWISSPROT;Acc:Q96C90]	cytoplasm	cellular component
			protein phosphatase inhibitor activity	molecular function
2.75593	down	ubiquilin-like [RefSeq_peptide;Acc:NP_659490]	protein modification process	biological process
2.79087		leucine-rich repeat neuronal 6A [RefSeq_peptide;Acc:NP_116197]	defense response
			integral to membrane	cellular component
			membrane
			protein binding	molecular function
2.83611		SERTA domain-containing protein 3 (Replication protein-binding trans- activator) (RPA-binding trans-activator). [Uniprot/SWISSPROT;Acc:Q9UJW9]	negative regulation of cell growth	biological process
			nucleus	cellular component
			positive regulation of transcription	biological process
			protein binding	molecular function
			regulation of transcription, DNA-dependent	biological process
			transcription
			transcriptional activator activity	molecular function
2.8521	up	transient receptor potential cation channel, subfamily M, member 1 [RefSeq_peptide;Acc:NP_002411]	calcium channel activity
			integral to plasma membrane	cellular component
			ion channel activity	molecular function
			ion transport	biological process
			membrane	cellular component
			membrane fraction
2.85383	down	Uncharacterized protein C20orf142 precursor. [Uniprot/SWISSPROT;Acc:Q8N6M3]	integral to membrane
			membrane
2.86298	up	T-brain-1 protein (T-box brain protein 1) (TBR-1) (TES-56). [Uniprot/SWISSPROT;Acc:Q16650]	brain development	biological process
			DNA binding	molecular function
			ligand-dependent nuclear receptor activity

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.