MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Class	Ratio	Regulation	Gene Ontology	description	Gene	Minimum Ratio	Accession	Maximum Ratio

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Showing element 651 to 700 of 2667 in total

Class  : biological process

Ratio	Regulation	Gene Ontology	description
2.12709	down	tRNA processing	Ribonuclease P protein subunit p29 (EC 3.1.26.5) (hPOP4). [Uniprot/SWISSPROT;Acc:O95707]
2.16131		translation	39S ribosomal protein L15, mitochondrial precursor (L15mt) (MRP-L15). [Uniprot/SWISSPROT;Acc:Q9P015]
2.20843	up	glucose transport	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes). [Uniprot/SWISSPROT;Acc:P07947]
		intracellular signaling cascade
		protein amino acid autophosphorylation
		protein amino acid phosphorylation
		protein modification process
2.25955	down	threonyl-tRNA aminoacylation	Threonyl-tRNA synthetase, mitochondrial precursor (EC 6.1.1.3) (Threonine--tRNA ligase) (ThrRS) (Threonyl-tRNA synthetase-like 1). [Uniprot/SWISSPROT;Acc:Q9BW92]
		translation
		tRNA aminoacylation for protein translation
2.2866	up	positive regulation of I-kappaB kinase/NF-kappaB cascade	Protein phosphatase 1A (EC 3.1.3.16) (Protein phosphatase 2C isoform alpha) (PP2C-alpha) (IA). [Uniprot/SWISSPROT;Acc:P35813]
		protein amino acid dephosphorylation
2.29381		cell death	Ataxin-7 (Spinocerebellar ataxia type 7 protein). [Uniprot/SWISSPROT;Acc:O15265]
		nuclear organization and biogenesis
		visual perception
2.2939		organelle organization and biogenesis	Hermansky-Pudlak syndrome 3 protein. [Uniprot/SWISSPROT;Acc:Q969F9]
		pigmentation
2.31039		maintenance of protein localization in nucleus	STAGA complex 65 subunit gamma (STAF65gamma) (SPTF-associated factor 65 gamma) (Suppressor of Ty 7-like) (Adenocarcinoma antigen ART1). [Uniprot/SWISSPROT;Acc:O94864]
		regulation of transcription, DNA-dependent
		transcription
2.31699	down	protein amino acid dephosphorylation	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform (EC 3.1.3.16) (PP2A-beta). [Uniprot/SWISSPROT;Acc:P62714]
2.33107		ubiquitin cycle	F-box only protein 15. [Uniprot/SWISSPROT;Acc:Q8NCQ5]
2.43098	up	lipid transport	Oxysterol-binding protein-related protein 2 (OSBP-related protein 2) (ORP-2). [Uniprot/SWISSPROT;Acc:Q9H1P3]
		steroid metabolic process
2.44552	down	G-protein coupled receptor protein signaling pathway	Guanine nucleotide-binding protein alpha-14 subunit (G-protein alpha subunit 14). [Uniprot/SWISSPROT;Acc:O95837]
		protein amino acid ADP-ribosylation
		signal transduction
2.45383		translation	40S ribosomal protein S2 (S4) (LLRep3 protein). [Uniprot/SWISSPROT;Acc:P15880]
2.45764	up	cation transport	zinc transporter like 2 [RefSeq_peptide;Acc:NP_598003]
		zinc ion transport
2.45875		proteolysis	ADAMTS-19 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 19) (ADAM-TS 19) (ADAM-TS19). [Uniprot/SWISSPROT;Acc:Q8TE59]
2.48474		ER to Golgi vesicle-mediated transport	BET1 homolog (Golgi vesicular membrane-trafficking protein p18) (hBET1). [Uniprot/SWISSPROT;Acc:O15155]
		protein transport
2.49031		nervous system development	Amyloid beta A4 precursor protein-binding family A member 2 (Neuron- specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2) (Adapter protein X11beta). [Uniprot/SWISSPROT;Acc:Q99767]
		protein transport
2.4954		proteolysis	OMA1 homolog, zinc metallopeptidase [RefSeq_peptide;Acc:NP_660286]
2.51088	down	lipid metabolic process	Epididymal-specific lipocalin-12 precursor. [Uniprot/SWISSPROT;Acc:Q6JVE5]
		transport
2.54508	up	cell adhesion	Neuroligin-2 precursor. [Uniprot/SWISSPROT;Acc:Q8NFZ4]
		cell-cell adhesion
		intercellular junction maintenance
		synaptogenesis
2.58329	down	cell differentiation	Myelin transcription factor 1-like protein (MyT1L protein) (MyT1-L). [Uniprot/SWISSPROT;Acc:Q9UL68]
		multicellular organismal development
		nervous system development
		regulation of transcription, DNA-dependent
		transcription
2.61135		DNA damage response, detection of DNA damage	28S ribosomal protein S35, mitochondrial precursor (S35mt) (MRP-S35) (Mitochondrial ribosomal protein S28) (MRP-S28). [Uniprot/SWISSPROT;Acc:P82673]
		peptide biosynthetic process
2.65068	up	complement activation	NULL

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.