MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	description	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1 to 50 of 2667 in total

Ratio	Regulation	description	Class	Gene Ontology
1.07618	up	U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit- related protein 2 (U2(RNU2) small nuclear RNA auxiliary factor 1-like 2) (CCCH type zinc finger, RNA-binding motif and serine/arginine rich protein 2) (Renal carcinoma antigen NY-REN-20). [Uniprot/SWISSPROT;Acc:Q15696]	biological process	G-protein coupled receptor protein signaling pathway
				RNA splicing
			cellular component	integral to membrane
				nucleus
				ribonucleoprotein complex
				U12-dependent spliceosome
			molecular function	metal ion binding
				nucleic acid binding
				nucleotide binding
				rhodopsin-like receptor activity
				RNA binding
				zinc ion binding
1.08658	down	pyrin and HIN domain family, member 1 alpha 1 isoform [RefSeq_peptide;Acc:NP_689714]		protein binding
1.10233	up	GAS2-like protein 1 (Growth arrest-specific 2-like 1) (GAS2-related protein on chromosome 22) (GAR22 protein). [Uniprot/SWISSPROT;Acc:Q99501]	biological process	cell cycle arrest
			cellular component	cytoplasm
				cytoskeleton
1.10831		Procollagen C-endopeptidase enhancer 1 precursor (Procollagen COOH- terminal proteinase enhancer 1) (Procollagen C-proteinase enhancer 1) (PCPE-1) (Type I procollagen COOH-terminal proteinase enhancer) (Type 1 procollagen C-proteinase enhancer protein). [Uniprot/SWISSPROT;Acc:Q15113]	biological process	multicellular organismal development
			molecular function	collagen binding
1.10867		Somatoliberin precursor (Growth hormone-releasing factor) (GRF) (Growth hormone-releasing hormone) (GHRH) (Somatocrinin) (Somatorelin) (Sermorelin). [Uniprot/SWISSPROT;Acc:P01286]	biological process	adenohypophysis development
				cell-cell signaling
				elevation of cytosolic calcium ion concentration
				G-protein signaling, adenylate cyclase activating pathway
				growth hormone secretion
				positive regulation of body size
				positive regulation of cAMP metabolic process
				positive regulation of growth hormone secretion
				positive regulation of hormone secretion
				positive regulation of transcription
				signal transduction
			cellular component	extracellular region
				terminal button
			molecular function	growth hormone-releasing hormone activity
				growth hormone-releasing hormone receptor binding
				hormone activity
1.10889		Nuclear receptor-binding factor 2 (NRBF-2) (Comodulator of PPAR and RXR). [Uniprot/SWISSPROT;Acc:Q96F24]	biological process	regulation of transcription, DNA-dependent
				transcription
			cellular component	cytoplasm
				nucleus
			molecular function	protein dimerization activity
				sequence-specific DNA binding
				transcription factor activity
1.11083	down	Sodium- and chloride-dependent transporter XTRP3 (Solute carrier family 6 member 20) (Neurotransmitter transporter rB21A homolog). [Uniprot/SWISSPROT;Acc:Q9NP91]	biological process	neurotransmitter transport
			cellular component	integral to plasma membrane
				membrane
				plasma membrane
			molecular function	neurotransmitter:sodium symporter activity
				symporter activity
				transporter activity
1.11519	up	eukaryotic translation initiation factor 4E family member 1B (EIF4E1B), mRNA [RefSeq_dna;Acc:NM_001099408]	biological process	translational initiation
			cellular component	cytoplasm

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.