MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	description	Class	Gene Ontology	Accession	Gene	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 151 to 200 of 2667 in total

Ratio	Regulation	description	Class	Gene Ontology
1.16499	up	ADAM 22 precursor (A disintegrin and metalloproteinase domain 22) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 2) (Metalloproteinase-disintegrin ADAM22-3). [Uniprot/SWISSPROT;Acc:Q9P0K1]	molecular function	zinc ion binding
1.16823		S-phase kinase-associated protein 2 (F-box protein Skp2) (Cyclin A/CDK2-associated protein p45) (p45skp2) (F-box/LRR-repeat protein 1). [Uniprot/SWISSPROT;Acc:Q13309]	biological process	cell proliferation
				G1/S transition of mitotic cell cycle
				regulation of progression through cell cycle
				ubiquitin cycle
			molecular function	protein binding
1.16921		Transcription cofactor HES-6 (Hairy and enhancer of split 6) (C- HAIRY1). [Uniprot/SWISSPROT;Acc:Q96HZ4]	biological process	cell differentiation
				multicellular organismal development
				nervous system development
				regulation of transcription
				regulation of transcription from RNA polymerase II promoter
				regulation of transcription, DNA-dependent
			cellular component	nucleus
				transcription factor complex
			molecular function	DNA binding
				transcription cofactor activity
				transcription factor activity
				transcription regulator activity
1.17398		Ectonucleoside triphosphate diphosphohydrolase 5 precursor (EC 3.6.1.6) (NTPDase 5) (Nucleoside diphosphatase) (CD39 antigen-like 4) (ER-UDPase). [Uniprot/SWISSPROT;Acc:O75356]	cellular component	endoplasmic reticulum
				integral to membrane
				membrane
			molecular function	calcium ion binding
				hydrolase activity
				magnesium ion binding
				nucleoside-diphosphatase activity
1.17693		Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1). [Uniprot/SWISSPROT;Acc:Q9H4M7]	biological process	biological_process
			cellular component	cellular_component
				cytoplasm
				membrane
			molecular function	lipid binding
				phosphatidylinositol binding
1.17859	down	XK-related protein 5. [Uniprot/SWISSPROT;Acc:Q6UX68]	cellular component	integral to membrane
				membrane
1.17879	up	Potassium voltage-gated channel subfamily KQT member 4 (Voltage-gated potassium channel subunit Kv7.4) (Potassium channel subunit alpha KvLQT4) (KQT-like 4). [Uniprot/SWISSPROT;Acc:P56696]	biological process	inner ear morphogenesis
				ion transport
				potassium ion transport
				sensory perception of sound
			cellular component	membrane
				membrane fraction
				voltage-gated potassium channel complex
			molecular function	ion channel activity
				potassium ion binding
				voltage-gated ion channel activity
				voltage-gated potassium channel activity
1.18096	down	Prostaglandin G/H synthase 2 precursor (EC 1.14.99.1) (Cyclooxygenase- 2) (COX-2) (Prostaglandin-endoperoxide synthase 2) (Prostaglandin H2 synthase 2) (PGH synthase 2) (PGHS-2) (PHS II). [Uniprot/SWISSPROT;Acc:P35354]	biological process	anagen
				blood pressure regulation
				cell motility
				cyclooxygenase pathway
				electron transport
				fatty acid biosynthetic process

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.