MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Regulation	Ratio	description	Gene Ontology	Class	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 393 to 442 of 2667 in total

Regulation  : down

Ratio	description	Gene Ontology	Class
1.30869	E3 ubiquitin-protein ligase CHFR (EC 6.3.2.-) (Checkpoint with forkhead and RING finger domains protein) (RING finger protein 196). [Uniprot/SWISSPROT;Acc:Q96EP1]	protein binding	molecular function
		protein polyubiquitination	biological process
		ubiquitin cycle
		ubiquitin-dependent protein catabolic process
		ubiquitin-protein ligase activity	molecular function
		zinc ion binding
1.31489	Tripartite motif-containing protein 58 (Protein BIA2). [Uniprot/SWISSPROT;Acc:Q8NG06]	intracellular	cellular component
		metal ion binding	molecular function
		protein binding
		zinc ion binding
1.32602	CDNA: FLJ22222 fis, clone HRC01658. [Uniprot/SPTREMBL;Acc:Q9H6J2]	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
		protein metabolic process	biological process
1.33817	Gamma-aminobutyric acid receptor-associated protein-like 1 (GABA(A) receptor-associated protein-like 1) (Glandular epithelial cell protein 1) (GEC-1) (Early estrogen-regulated protein). [Uniprot/SWISSPROT;Acc:Q9H0R8]	autophagic vacuole	cellular component
		autophagic vacuole formation	biological process
		beta-tubulin binding	molecular function
		cytoplasm	cellular component
		GABA receptor binding	molecular function
		intracellular	cellular component
		microtubule
		protein binding	molecular function
1.351	TBK1 binding protein 1 [RefSeq_peptide;Acc:NP_055541]	dopamine receptor activity
		G-protein coupled receptor protein signaling pathway	biological process
		integral to membrane	cellular component
1.36349	Cyclin-I. [Uniprot/SWISSPROT;Acc:Q14094]	regulation of progression through cell cycle	biological process
		spermatogenesis
1.36755	Nucleolar preribosomal-associated protein 1 (Fragment). [Uniprot/SWISSPROT;Acc:O60287]	biological_process
		molecular_function	molecular function
		nucleolus	cellular component
		nucleus
1.36911	Orexigenic neuropeptide QRFP receptor (G-protein coupled receptor 103) (SP9155) (AQ27). [Uniprot/SWISSPROT;Acc:Q96P65]	bombesin receptor activity	molecular function
		G-protein coupled receptor protein signaling pathway	biological process
		integral to membrane	cellular component
		membrane
		metabotropic glutamate, GABA-B-like receptor activity	molecular function
		neuropeptide receptor activity
		neuropeptide Y receptor activity
		orexin receptor activity
		purinergic nucleotide receptor activity, G-protein coupled
		receptor activity
		rhodopsin-like receptor activity
		signal transduction	biological process
1.40451	COX16-like protein C14orf112, mitochondrial precursor. [Uniprot/SWISSPROT;Acc:Q9P0S2]	integral to membrane	cellular component
		membrane
		mitochondrion
1.40552	Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) (Amino acid transporter ATB0+) (Solute carrier family 6 member 14). [Uniprot/SWISSPROT;Acc:Q9UN76]	amino acid metabolic process	biological process
		amino acid transport
		amino acid transporter activity	molecular function
		dicarboxylic acid transport	biological process
		integral to plasma membrane	cellular component
		membrane

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.