MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	description	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 2619 to 2667 of 2667 in total

Ratio	Regulation	description	Class	Gene Ontology
5.84607	down	Tubulin-specific chaperone E (Tubulin-folding cofactor E). [Uniprot/SWISSPROT;Acc:Q15813]	biological process	microtubule cytoskeleton organization and biogenesis
				protein folding
				protein modification process
			cellular component	cytoplasm
				cytoskeleton
				microtubule
			molecular function	chaperone binding
				protein binding
6.3909		Protein Jade-1 (PHD finger protein 17). [Uniprot/SWISSPROT;Acc:Q6IE81]	biological process	apoptosis
				intracellular signaling cascade
				negative regulation of cell growth
				regulation of transcription, DNA-dependent
				response to stress
				transcription
			cellular component	cytoplasm
				nucleus
			molecular function	metal ion binding
				protein binding
				zinc ion binding
6.50865	up	Serine/threonine-protein kinase Nek10 (EC 2.7.11.1) (NimA-related protein kinase 10). [Uniprot/SWISSPROT;Acc:Q6ZWH5]	biological process	protein amino acid phosphorylation
			molecular function	ATP binding
				magnesium ion binding
				nucleotide binding
				protein kinase activity
				protein serine/threonine kinase activity
				protein-tyrosine kinase activity
				transferase activity
6.56408	down	DNA-directed RNA polymerase III subunit RPC8 (RNA polymerase III subunit C8) (DNA-directed RNA polymerase III subunit H) (DNA-directed RNA polymerase III subunit 22.9 kDa polypeptide). [Uniprot/SWISSPROT;Acc:Q9Y535]	biological process	transcription
				transcription from RNA polymerase III promoter
			cellular component	DNA-directed RNA polymerase III complex
				nucleoplasm
				nucleus
			molecular function	DNA-directed RNA polymerase activity
				protein binding
7.27043	up	Short palate, lung and nasal epithelium carcinoma-associated protein 3 precursor. [Uniprot/SWISSPROT;Acc:Q9BQP9]		lipid binding
7.45006	down	MAP7 domain containing 1 [RefSeq_peptide;Acc:NP_060537]	biological process	G-protein coupled receptor protein signaling pathway
			cellular component	integral to membrane
			molecular function	histamine receptor activity
				structural constituent of cell wall
8.21788	up	Ubiquitin-activating enzyme E1 domain-containing protein 1 (UFM1- activating enzyme) (Ubiquitin-activating enzyme 5) (ThiFP1). [Uniprot/SWISSPROT;Acc:Q9GZZ9]	biological process	defense response
				humoral immune response
				ubiquitin cycle
			cellular component	cytoplasm
				nucleus
			molecular function	catalytic activity
				cofactor binding
				DNA binding
				oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
				translation regulator activity

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.