MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Regulation	Ratio	Gene Ontology	description	Accession	Class	Gene	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 2001 to 2050 of 2667 in total

Regulation  : up

Ratio	Gene Ontology	description	Class
1.75026	axon ensheathment	Claudin-11 (Oligodendrocyte-specific protein). [Uniprot/SWISSPROT;Acc:O75508]	biological process
	calcium-independent cell-cell adhesion
	cell adhesion
	cell junction		cellular component
	identical protein binding		molecular function
	integral to membrane		cellular component
	membrane
	spermatogenesis		biological process
	structural molecule activity		molecular function
	tight junction		cellular component
1.78439	ATP binding	Chromodomain helicase-DNA-binding protein 4 (EC 3.6.1.-) (ATP- dependent helicase CHD4) (CHD-4) (Mi-2 autoantigen 218 kDa protein) (Mi2-beta). [Uniprot/SWISSPROT;Acc:Q14839]	molecular function
	ATP-dependent DNA helicase activity
	ATP-dependent helicase activity
	chromatin		cellular component
	chromatin assembly or disassembly		biological process
	chromatin binding		molecular function
	chromatin modification		biological process
	chromosome organization and biogenesis (sensu Eukaryota)
	DNA binding		molecular function
	helicase activity
	hydrolase activity
	intracellular signaling cascade		biological process
	metal ion binding		molecular function
	nucleic acid binding
	nucleotide binding
	nucleus		cellular component
	protein binding		molecular function
	regulation of transcription from RNA polymerase II promoter		biological process
	transcription
	transcription factor binding		molecular function
	zinc ion binding
1.78708	chromosome	Centromere protein L (CENP-L) (Interphase centromere complex protein 33). [Uniprot/SWISSPROT;Acc:Q8N0S6]	cellular component
	chromosome, pericentric region
	nucleus
1.79094	binding	Protein FAM65A. [Uniprot/SWISSPROT;Acc:Q6ZS17]	molecular function
	intracellular		cellular component
	signal transduction		biological process
1.7961	GTP binding	RAS-like, family 11, member A [RefSeq_peptide;Acc:NP_996563]	molecular function
	intracellular		cellular component
	nucleotide binding		molecular function
	protein transport		biological process
	small GTPase mediated signal transduction
1.83496	ceramide metabolic process	Protein FAN (Factor associated with N-SMase activation) (Factor associated with neutral sphingomyelinase activation). [Uniprot/SWISSPROT;Acc:Q92636]
	cytoplasm		cellular component
	receptor signaling protein activity		molecular function
	signal transduction		biological process
	soluble fraction		cellular component
1.83601	G-protein coupled receptor protein signaling pathway	coiled-coil domain containing 90A [RefSeq_peptide;Acc:NP_001026883]	biological process
	integral to membrane		cellular component
	membrane

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.