MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Regulation	Gene Ontology	Ratio	description	Accession	Class	Gene	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 2051 to 2100 of 2667 in total

Regulation  : up

Gene Ontology	Ratio	description	Class
nucleus	1.50206	LAG1 longevity assurance homolog 4. [Uniprot/SWISSPROT;Acc:Q9HA82]	cellular component
	1.57088	Forkhead box protein P2 (CAG repeat protein 44) (Trinucleotide repeat- containing gene 10 protein). [Uniprot/SWISSPROT;Acc:O15409]
	1.59188	Zinc finger protein 384 (Nuclear matrix transcription factor 4) (Nuclear matrix protein 4) (CAG repeat protein 1) (CAS-interacting zinc finger protein) (Trinucleotide repeat-containing gene 1 protein). [Uniprot/SWISSPROT;Acc:Q8TF68]
	1.61673	Calcium/calmodulin-dependent protein kinase type 1B (EC 2.7.11.17) (CaM kinase IB) (CaM kinase I beta) (CaMKI-beta) (CaM-KI beta) (Pregnancy up-regulated non-ubiquitously expressed CaM kinase). [Uniprot/SWISSPROT;Acc:Q6P2M8]
	1.66679	TCDD-inducible poly [ADP-ribose] polymerase (EC 2.4.2.30) (Poly [ADP- ribose] polymerase 7) (PARP-7). [Uniprot/SWISSPROT;Acc:Q7Z3E1]
	1.69345	GC-rich sequence DNA-binding factor (GCF) (Transcription factor 9) (TCF-9). [Uniprot/SWISSPROT;Acc:P16383]
	1.78439	Chromodomain helicase-DNA-binding protein 4 (EC 3.6.1.-) (ATP- dependent helicase CHD4) (CHD-4) (Mi-2 autoantigen 218 kDa protein) (Mi2-beta). [Uniprot/SWISSPROT;Acc:Q14839]
	1.78708	Centromere protein L (CENP-L) (Interphase centromere complex protein 33). [Uniprot/SWISSPROT;Acc:Q8N0S6]
	1.93995	Zinc finger protein ubi-d4 (Requiem) (Apoptosis response zinc finger protein) (D4, zinc and double PHD fingers family 2). [Uniprot/SWISSPROT;Acc:Q92785]
	2.10428	Transcription factor AP-1 (Activator protein 1) (AP1) (Proto-oncogene c-jun) (V-jun avian sarcoma virus 17 oncogene homolog) (p39). [Uniprot/SWISSPROT;Acc:P05412]
	2.29381	Ataxin-7 (Spinocerebellar ataxia type 7 protein). [Uniprot/SWISSPROT;Acc:O15265]
	2.31039	STAGA complex 65 subunit gamma (STAF65gamma) (SPTF-associated factor 65 gamma) (Suppressor of Ty 7-like) (Adenocarcinoma antigen ART1). [Uniprot/SWISSPROT;Acc:O94864]
	2.7017	Centromere protein S (CENP-S) (Apoptosis-inducing TAF9-like domain- containing protein 1). [Uniprot/SWISSPROT;Acc:Q8N2Z9]
	2.72371	Opa-interacting protein 5. [Uniprot/SWISSPROT;Acc:O43482]
	2.86298	T-brain-1 protein (T-box brain protein 1) (TBR-1) (TES-56). [Uniprot/SWISSPROT;Acc:Q16650]
	2.86965	RNA-binding protein 28 (RNA-binding motif protein 28). [Uniprot/SWISSPROT;Acc:Q9NW13]
	2.87038	Calpain-3 (EC 3.4.22.54) (Calpain L3) (Calpain p94) (Calcium-activated neutral proteinase 3) (CANP 3) (Muscle-specific calcium-activated neutral protease 3) (nCL-1). [Uniprot/SWISSPROT;Acc:P20807]
	2.91954	Cisplatin resistance-associated overexpressed protein (cAMP regulatory element-associated protein 1) (CRE-associated protein 1) (CREAP-1) (Luc7A) (Okadaic acid-inducible phosphoprotein OA48-18). [Uniprot/SWISSPROT;Acc:O95232]
	2.95579	Protein phosphatase Slingshot homolog 3 (EC 3.1.3.48) (EC 3.1.3.16) (SSH-3L) (hSSH-3L). [Uniprot/SWISSPROT;Acc:Q8TE77]
	2.96739	Protein FRA10AC1. [Uniprot/SWISSPROT;Acc:Q70Z53]
	3.35536	RNA polymerase-associated protein RTF1 homolog. [Uniprot/SWISSPROT;Acc:Q92541]
	3.36725	TAR RNA-binding protein 2 (Trans-activation-responsive RNA-binding protein). [Uniprot/SWISSPROT;Acc:Q15633]
	3.70292	Homeobox protein SIX4 (Sine oculis homeobox homolog 4). [Uniprot/SWISSPROT;Acc:Q9UIU6]
	3.81736	Transcription factor E2F3 (E2F-3). [Uniprot/SWISSPROT;Acc:O00716]
	4.04651	Sad1/unc-84-like protein 2 (Rab5-interacting protein) (Rab5IP). [Uniprot/SWISSPROT;Acc:Q9UH99]
	4.14054	Protein odd-skipped-related 2. [Uniprot/SWISSPROT;Acc:Q8N2R0]
	4.55177	Transcription factor SOX-14. [Uniprot/SWISSPROT;Acc:O95416]
	4.55371	Parathyroid hormone/parathyroid hormone-related peptide receptor precursor (PTH/PTHr receptor) (PTH/PTHrP type I receptor). [Uniprot/SWISSPROT;Acc:Q03431]
	5.81102	PDZ and LIM domain protein 2 (PDZ-LIM protein mystique) (PDZ-LIM protein). [Uniprot/SWISSPROT;Acc:Q96JY6]
	8.21788	Ubiquitin-activating enzyme E1 domain-containing protein 1 (UFM1- activating enzyme) (Ubiquitin-activating enzyme 5) (ThiFP1). [Uniprot/SWISSPROT;Acc:Q9GZZ9]
olfactory receptor activity	1.16393	olfactory receptor, family 5, subfamily K, member 4 [RefSeq_peptide;Acc:NP_001005517]	molecular function
	1.6384	Olfactory receptor 6S1. [Uniprot/SWISSPROT;Acc:Q8NH40]
	1.93863	Olfactory receptor 2B2 (Olfactory receptor 6-1) (OR6-1) (Hs6M1-10). [Uniprot/SWISSPROT;Acc:Q9GZK3]
	2.86538	Olfactory receptor 1J2 (Olfactory receptor OR9-19) (OST044) (HSA5) (HTPCRX15). [Uniprot/SWISSPROT;Acc:Q8NGS2]
oligosaccharyl transferase activity	1.54317	Dolichyl-phosphate beta-glucosyltransferase (EC 2.4.1.117) (DolP- glucosyltransferase). [Uniprot/SWISSPROT;Acc:Q9Y673]
organ morphogenesis	1.35125	Geminin. [Uniprot/SWISSPROT;Acc:O75496]	biological process
organelle organization and biogenesis	2.2939	Hermansky-Pudlak syndrome 3 protein. [Uniprot/SWISSPROT;Acc:Q969F9]
osmosensory signaling pathway	1.60668	Transient receptor potential cation channel subfamily V member 4 (TrpV4) (osm-9-like TRP channel 4) (OTRPC4) (Vanilloid receptor-like channel 2) (Vanilloid receptor-like protein 2) (VRL-2) (Vanilloid receptor-related osmotically-activated channel) (VR-OAC [Uniprot/SWISSPROT;Acc:Q9HBA0]
outward rectifier potassium channel activity	4.67988	Potassium voltage-gated channel subfamily A member 3 (Voltage-gated potassium channel subunit Kv1.3) (HPCN3) (HGK5) (HuKIII) (HLK3). [Uniprot/SWISSPROT;Acc:P22001]	molecular function
oxidized purine base lesion DNA N-glycosylase activity	1.35022	N-glycosylase/DNA lyase [Includes: 8-oxoguanine DNA glycosylase (EC 3.2.2.-); DNA-(apurinic or apyrimidinic site) lyase (EC 4.2.99.18) (AP lyase)]. [Uniprot/SWISSPROT;Acc:O15527]
oxidoreductase activity	1.19496	Isocitrate dehydrogenase [NADP] cytoplasmic (EC 1.1.1.42) (Cytosolic NADP-isocitrate dehydrogenase) (Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific ICDH) (IDP). [Uniprot/SWISSPROT;Acc:O75874]
	1.20102	Metalloreductase STEAP3 (EC 1.16.1.-) (Six-transmembrane epithelial antigen of prostate 3) (Tumor suppressor-activated pathway protein 6) (hTSAP6) (pHyde) (hpHyde) (Dudulin-2). [Uniprot/SWISSPROT;Acc:Q658P3]
	1.21698	Kelch-like protein 34. [Uniprot/SWISSPROT;Acc:Q8N239]
	1.25729	Dehydrogenase/reductase SDR family member 1 (EC 1.1.-.-). [Uniprot/SWISSPROT;Acc:Q96LJ7]
	1.29238	Coiled-coil and C2 domain-containing protein 1B. [Uniprot/SWISSPROT;Acc:Q5T0F9]
	3.74971	Glutathione peroxidase 6 precursor (EC 1.11.1.9). [Uniprot/SWISSPROT;Acc:P59796]
	4.40598	GMP reductase 1 (EC 1.7.1.7) (Guanosine 5'-monophosphate oxidoreductase 1) (Guanosine monophosphate reductase 1). [Uniprot/SWISSPROT;Acc:P36959]
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	1.49264	Cytochrome P450 2W1 (EC 1.14.14.-) (CYPIIW1). [Uniprot/SWISSPROT;Acc:Q8TAV3]
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	1.19496	Isocitrate dehydrogenase [NADP] cytoplasmic (EC 1.1.1.42) (Cytosolic NADP-isocitrate dehydrogenase) (Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific ICDH) (IDP). [Uniprot/SWISSPROT;Acc:O75874]
	8.21788	Ubiquitin-activating enzyme E1 domain-containing protein 1 (UFM1- activating enzyme) (Ubiquitin-activating enzyme 5) (ThiFP1). [Uniprot/SWISSPROT;Acc:Q9GZZ9]

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.