MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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description	Ratio	Regulation	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 2490 to 2539 of 2667 in total

description	Ratio	Regulation	Class	Gene Ontology
Tubulin-specific chaperone E (Tubulin-folding cofactor E). [Uniprot/SWISSPROT;Acc:Q15813]	5.84607	down	molecular function	protein binding
Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48) (His domain-containing protein tyrosine phosphatase) (HD-PTP) (Protein tyrosine phosphatase TD14) (PTP-TD14). [Uniprot/SWISSPROT;Acc:Q9H3S7]	1.62709	up	biological process	dephosphorylation
				protein amino acid dephosphorylation
			cellular component	cytoplasmic vesicle
			molecular function	hydrolase activity
				phosphoric monoester hydrolase activity
				protein tyrosine phosphatase activity
U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit- related protein 2 (U2(RNU2) small nuclear RNA auxiliary factor 1-like 2) (CCCH type zinc finger, RNA-binding motif and serine/arginine rich protein 2) (Renal carcinoma antigen NY-REN-20). [Uniprot/SWISSPROT;Acc:Q15696]	1.07618		biological process	G-protein coupled receptor protein signaling pathway
				RNA splicing
			cellular component	integral to membrane
				nucleus
				ribonucleoprotein complex
				U12-dependent spliceosome
			molecular function	metal ion binding
				nucleic acid binding
				nucleotide binding
				rhodopsin-like receptor activity
				RNA binding
				zinc ion binding
ubiquilin-like [RefSeq_peptide;Acc:NP_659490]	2.75593	down	biological process	protein modification process
Ubiquitin-activating enzyme E1 domain-containing protein 1 (UFM1- activating enzyme) (Ubiquitin-activating enzyme 5) (ThiFP1). [Uniprot/SWISSPROT;Acc:Q9GZZ9]	8.21788	up		defense response
				humoral immune response
				ubiquitin cycle
			cellular component	cytoplasm
				nucleus
			molecular function	catalytic activity
				cofactor binding
				DNA binding
				oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
				translation regulator activity
Ubiquitin-conjugating enzyme E2 Q2 (EC 6.3.2.19) (Ubiquitin-protein ligase Q2) (Ubiquitin carrier protein Q2). [Uniprot/SWISSPROT;Acc:Q8WVN8]	1.59763	down	biological process	protein modification process
				ubiquitin cycle
			cellular component	cytoplasm
			molecular function	ATP binding
				ligase activity
				nucleotide binding
				small conjugating protein ligase activity
				ubiquitin-protein ligase activity
Ubiquitin-conjugating enzyme E2 R2 (EC 6.3.2.19) (Ubiquitin-protein ligase R2) (Ubiquitin carrier protein R2) (E2-CDC34B). [Uniprot/SWISSPROT;Acc:Q712K3]	1.49444	up	biological process	protein modification process
				ubiquitin cycle
			molecular function	ligase activity
				small conjugating protein ligase activity
				ubiquitin-protein ligase activity
Ufm1-specific protease 2 (EC 3.4.22.-) (UfSP2). [Uniprot/SWISSPROT;Acc:Q9NUQ7]	5.01332		biological process	ubiquitin cycle
			molecular function	cysteine-type peptidase activity
				thiolester hydrolase activity
Uncharacterized protein C16orf48. [Uniprot/SWISSPROT;Acc:Q9H0I2]	1.27516		cellular component	microtubule cytoskeleton
Uncharacterized protein C17orf56. [Uniprot/SWISSPROT;Acc:Q96N21]	4.21401	down		membrane
Uncharacterized protein C18orf26. [Uniprot/SWISSPROT;Acc:Q8N1N2]	1.80942			integral to membrane
				membrane

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.