MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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description	Ratio	Regulation	Gene	Gene Ontology	Accession	Class	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 951 to 1000 of 2667 in total

description	Ratio	Regulation	Gene Ontology	Class
Golgin subfamily B member 1 (Giantin) (Macrogolgin) (372 kDa Golgi complex-associated protein) (GCP372). [Uniprot/SWISSPROT;Acc:Q14789]	1.45148	up	regulation of transcription, DNA-dependent	biological process
			vesicle-mediated transport
Growth/differentiation factor 2 precursor (GDF-2) (Bone morphogenetic protein 9) (BMP-9). [Uniprot/SWISSPROT;Acc:Q9UK05]	3.11758	down	cytokine activity	molecular function
			extracellular region	cellular component
			extracellular space
			growth	biological process
			growth factor activity	molecular function
GTP-binding protein Rhes precursor (Ras homolog enriched in striatum) (Tumor endothelial marker 2). [Uniprot/SWISSPROT;Acc:Q96D21]	3.64872	up	cellular_component	cellular component
			GTP binding	molecular function
			GTPase activity
			intracellular	cellular component
			intracellular protein transport	biological process
			locomotory behavior
			membrane	cellular component
			nucleocytoplasmic transport	biological process
			nucleotide binding	molecular function
			protein binding
			protein transport	biological process
			signal transduction
			small GTPase mediated signal transduction
GTP-binding protein SAR1a (COPII-associated small GTPase). [Uniprot/SWISSPROT;Acc:Q9NR31]	1.40602		cytoplasm	cellular component
			endoplasmic reticulum
			ER to Golgi vesicle-mediated transport	biological process
			Golgi apparatus	cellular component
			GTP binding	molecular function
			GTPase activity
			intracellular	cellular component
			intracellular protein transport	biological process
			nucleotide binding	molecular function
			small GTPase mediated signal transduction	biological process
Guanine nucleotide-binding protein alpha-14 subunit (G-protein alpha subunit 14). [Uniprot/SWISSPROT;Acc:O95837]	2.44552	down	G-protein coupled receptor protein signaling pathway
			GTP binding	molecular function
			GTPase activity
			guanyl nucleotide binding
			heterotrimeric G-protein complex	cellular component
			nucleotide binding	molecular function
			plasma membrane	cellular component
			protein amino acid ADP-ribosylation	biological process
			signal transducer activity	molecular function
			signal transduction	biological process
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta 2 (Transducin beta chain 2) (G protein beta 2 subunit). [Uniprot/SWISSPROT;Acc:P62879]	3.54799		calcium channel regulator activity	molecular function
			G-protein coupled receptor protein signaling pathway	biological process
			GTPase activity	molecular function
			protein binding
			signal transducer activity
			signal transduction	biological process
Guanylate cyclase soluble subunit beta-2 (EC 4.6.1.2) (GCS-beta-2). [Uniprot/SWISSPROT;Acc:O75343]	1.18489	up	cGMP biosynthetic process
			cyclic nucleotide biosynthetic process
			cytoplasm	cellular component
			guanylate cyclase activity	molecular function

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.