MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	description	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 51 to 100 of 2667 in total

Ratio	Regulation	description	Class	Gene Ontology
1.11519	up	eukaryotic translation initiation factor 4E family member 1B (EIF4E1B), mRNA [RefSeq_dna;Acc:NM_001099408]	molecular function	RNA binding
				translation initiation factor activity
1.11956	down	Protein RER1. [Uniprot/SWISSPROT;Acc:O15258]	biological process	retrograde vesicle-mediated transport, Golgi to ER
			cellular component	Golgi apparatus
				integral to Golgi membrane
				integral to membrane
				membrane
			molecular function	molecular_function
1.12417	up	Protein CutA precursor (Brain acetylcholinesterase putative membrane anchor) (Acetylcholinesterase-associated protein). [Uniprot/SWISSPROT;Acc:O60888]	biological process	protein homooligomerization
				protein localization
				response to metal ion
			cellular component	membrane
			molecular function	enzyme binding
				protein heterodimerization activity
				retinoic acid receptor binding
				retinoid-X receptor activity
				thyroid hormone receptor binding
				thyroid hormone receptor coactivator activity
				vitamin D receptor binding
1.1243	down	Zinc finger protein basonuclin-2. [Uniprot/SWISSPROT;Acc:Q6ZN30]	biological process	regulation of transcription, DNA-dependent
				transcription
			cellular component	intracellular
				nucleus
			molecular function	DNA binding
				metal ion binding
				nucleic acid binding
				zinc ion binding
1.13007	up	Zinc finger protein 219. [Uniprot/SWISSPROT;Acc:Q9P2Y4]	biological process	anion transport
				G-protein coupled receptor protein signaling pathway
				regulation of transcription, DNA-dependent
			cellular component	integral to membrane
				intracellular
				membrane
				nucleus
			molecular function	histamine receptor activity
				inorganic anion exchanger activity
				metal ion binding
				nucleic acid binding
				transcription factor activity
				zinc ion binding
1.13541	down	Protein kinase C-binding protein NELL2 precursor (NEL-like protein 2) (Nel-related protein 2). [Uniprot/SWISSPROT;Acc:Q99435]	biological process	blood coagulation
				cell adhesion
				regulation of growth
			cellular component	extracellular region
				membrane
			molecular function	calcium ion binding
				protein binding
				structural molecule activity
				transmembrane receptor activity
1.14311		14-3-3 protein gamma (Protein kinase C inhibitor protein 1) (KCIP-1). [Uniprot/SWISSPROT;Acc:P61981]	biological process	negative regulation of protein kinase activity

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.