MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Regulation	Ratio	Gene Ontology	description	Class	Gene	Minimum Ratio	Accession	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1969 to 2018 of 2667 in total

Regulation  : up

Ratio	Gene Ontology	description	Class
1.66123	muscarinic acetylcholine receptor activity	KRAB-A domain containing 1 (KRBA1), mRNA [RefSeq_dna;Acc:NM_032534]	molecular function
	nucleic acid binding
	regulation of transcription, DNA-dependent		biological process
1.66679	metal ion binding	TCDD-inducible poly [ADP-ribose] polymerase (EC 2.4.2.30) (Poly [ADP- ribose] polymerase 7) (PARP-7). [Uniprot/SWISSPROT;Acc:Q7Z3E1]	molecular function
	NAD+ ADP-ribosyltransferase activity
	nucleic acid binding
	nucleus		cellular component
	protein amino acid ADP-ribosylation		biological process
	protein binding		molecular function
	transferase activity, transferring glycosyl groups
	zinc ion binding
1.69345	DNA binding	GC-rich sequence DNA-binding factor (GCF) (Transcription factor 9) (TCF-9). [Uniprot/SWISSPROT;Acc:P16383]
	nucleus		cellular component
	regulation of transcription		biological process
	regulation of transcription, DNA-dependent
	RNA polymerase II transcription factor activity		molecular function
	transcription factor activity
1.69856	ATP binding	Myosin light chain kinase 2, skeletal/cardiac muscle (EC 2.7.11.18) (MLCK2). [Uniprot/SWISSPROT;Acc:Q9H1R3]
	calmodulin binding
	cytoplasm		cellular component
	neuromuscular synaptic transmission		biological process
	nucleotide binding		molecular function
	protein amino acid phosphorylation		biological process
	protein kinase activity		molecular function
	protein serine/threonine kinase activity
	protein-tyrosine kinase activity
	transferase activity
1.73291	membrane	BTB/POZ domain-containing protein KCTD8. [Uniprot/SWISSPROT;Acc:Q6ZWB6]	cellular component
	potassium ion transport		biological process
	protein binding		molecular function
	voltage-gated potassium channel activity
	voltage-gated potassium channel complex		cellular component
1.75026	axon ensheathment	Claudin-11 (Oligodendrocyte-specific protein). [Uniprot/SWISSPROT;Acc:O75508]	biological process
	calcium-independent cell-cell adhesion
	cell adhesion
	cell junction		cellular component
	identical protein binding		molecular function
	integral to membrane		cellular component
	membrane
	spermatogenesis		biological process
	structural molecule activity		molecular function
	tight junction		cellular component
1.78439	ATP binding	Chromodomain helicase-DNA-binding protein 4 (EC 3.6.1.-) (ATP- dependent helicase CHD4) (CHD-4) (Mi-2 autoantigen 218 kDa protein) (Mi2-beta). [Uniprot/SWISSPROT;Acc:Q14839]	molecular function
	ATP-dependent DNA helicase activity
	ATP-dependent helicase activity
	chromatin		cellular component
	chromatin assembly or disassembly		biological process
	chromatin binding		molecular function
	chromatin modification		biological process
	chromosome organization and biogenesis (sensu Eukaryota)

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.