MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Gene Ontology	Regulation	description	Class	Gene	Minimum Ratio	Maximum Ratio	Accession

Results: HTML CSV LaTeX

Showing element 601 to 650 of 948 in total

Class  : biological process

Ratio	Gene Ontology	Regulation	description
1.86204	regulation of transcription, DNA-dependent	down	Zinc finger and SCAN domain-containing protein 4 (Zinc finger protein 494). [Uniprot/SWISSPROT;Acc:Q8NAM6]
	transcription
1.86433	cation transport	up	CKLF-like MARVEL transmembrane domain-containing protein 4 (Chemokine- like factor superfamily member 4). [Uniprot/SWISSPROT;Acc:Q8IZR5]
	chemotaxis
1.89168	lipid metabolic process	down	Zinc finger protein 202 (Zinc finger protein with KRAB and SCAN domains 10). [Uniprot/SWISSPROT;Acc:O95125]
	negative regulation of transcription from RNA polymerase II promoter
	regulation of transcription, DNA-dependent
	transcription
1.89308	intracellular protein transport	up	Ras-related protein Rab-36. [Uniprot/SWISSPROT;Acc:O95755]
	nucleocytoplasmic transport
	protein transport
	signal transduction
	small GTPase mediated signal transduction
1.93863	G-protein coupled receptor protein signaling pathway		Olfactory receptor 2B2 (Olfactory receptor 6-1) (OR6-1) (Hs6M1-10). [Uniprot/SWISSPROT;Acc:Q9GZK3]
	response to stimulus
	sensory perception of smell
	signal transduction
1.93995	apoptosis		Zinc finger protein ubi-d4 (Requiem) (Apoptosis response zinc finger protein) (D4, zinc and double PHD fingers family 2). [Uniprot/SWISSPROT;Acc:Q92785]
	induction of apoptosis by extracellular signals
	regulation of transcription, DNA-dependent
	transcription
1.95876	intracellular protein transport		Ras-related protein Rab-17. [Uniprot/SWISSPROT;Acc:Q9H0T7]
	nucleocytoplasmic transport
	protein transport
	signal transduction
	small GTPase mediated signal transduction
1.96673	proteolysis		Signal peptidase complex catalytic subunit SEC11C (EC 3.4.-.-) (SEC11 homolog C) (SEC11-like protein 3) (Microsomal signal peptidase 21 kDa subunit) (SPase 21 kDa subunit) (SPC21). [Uniprot/SWISSPROT;Acc:Q9BY50]
	signal peptide processing
1.98137	regulation of transcription, DNA-dependent	down	Nuclear receptor ROR-alpha (Retinoid-related orphan receptor-alpha) (Nuclear receptor RZR-alpha). [Uniprot/SWISSPROT;Acc:P35398]
	signal transduction
	transcription
1.98149	anti-apoptosis	up	CD40 ligand (CD40-L) (Tumor necrosis factor ligand superfamily member 5) (TNF-related activation protein) (TRAP) (T cell antigen Gp39) (CD154 antigen) [Contains: CD40 ligand, membrane form; CD40 ligand, soluble form]. [Uniprot/SWISSPROT;Acc:P29965]
	B cell differentiation
	B cell proliferation
	immune response
	inflammatory response
	isotype switching
	leukocyte adhesion
	platelet activation
	regulation of immunoglobulin secretion
2.07532	cytoskeletal anchoring		SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP). [Uniprot/SWISSPROT;Acc:Q9Y566]
2.08208	hyaluronan metabolic process	down	Inter-alpha-trypsin inhibitor heavy chain H2 precursor (ITI heavy chain H2) (Inter-alpha-inhibitor heavy chain 2) (Inter-alpha-trypsin inhibitor complex component II) (Serum-derived hyaluronan-associated protein) (SHAP). [Uniprot/SWISSPROT;Acc:P19823]
2.10428	cellular process	up	Transcription factor AP-1 (Activator protein 1) (AP1) (Proto-oncogene c-jun) (V-jun avian sarcoma virus 17 oncogene homolog) (p39). [Uniprot/SWISSPROT;Acc:P05412]
	leading edge cell differentiation
	negative regulation of protein amino acid autophosphorylation
	positive regulation of transcription from RNA polymerase II promoter
	regulation of progression through cell cycle
	regulation of transcription
	regulation of transcription, DNA-dependent
2.12709	rRNA processing	down	Ribonuclease P protein subunit p29 (EC 3.1.26.5) (hPOP4). [Uniprot/SWISSPROT;Acc:O95707]

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.