MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

Navigation/Query Panel:
Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].

Ratio	Regulation	description	Class	Gene Ontology	Accession	Gene	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 451 to 500 of 1031 in total

Class  : molecular function

Ratio	Regulation	description	Gene Ontology
1.49444	up	Ubiquitin-conjugating enzyme E2 R2 (EC 6.3.2.19) (Ubiquitin-protein ligase R2) (Ubiquitin carrier protein R2) (E2-CDC34B). [Uniprot/SWISSPROT;Acc:Q712K3]	ligase activity
			small conjugating protein ligase activity
			ubiquitin-protein ligase activity
1.49558	down	Bone morphogenetic protein 2 precursor (BMP-2) (BMP-2A). [Uniprot/SWISSPROT;Acc:P12643]	cytokine activity
			growth factor activity
			protein binding
			transforming growth factor beta receptor binding
1.49923		Rap guanine nucleotide exchange factor 1 (Guanine nucleotide-releasing factor 2) (C3G protein) (CRK SH3-binding GNRP). [Uniprot/SWISSPROT;Acc:Q13905]	guanyl-nucleotide exchange factor activity
			protein binding
1.50206	up	LAG1 longevity assurance homolog 4. [Uniprot/SWISSPROT;Acc:Q9HA82]	sequence-specific DNA binding
			transcription factor activity
1.50284	down	AP-3 complex subunit sigma-2 (Adapter-related protein complex 3 sigma- 2 subunit) (Sigma-adaptin 3b) (AP-3 complex sigma-3B subunit) (Sigma- 3B-adaptin). [Uniprot/SWISSPROT;Acc:P59780]	protein binding
			protein transporter activity
1.50715		F-box/WD repeat protein 5 (F-box and WD-40 domain protein 5). [Uniprot/SWISSPROT;Acc:Q969U6]	protein binding
1.5415		Pleckstrin homology-like domain family B member 2 (Protein LL5-beta). [Uniprot/SWISSPROT;Acc:Q86SQ0]	phospholipase C activity
			voltage-gated chloride channel activity
1.54317	up	Dolichyl-phosphate beta-glucosyltransferase (EC 2.4.1.117) (DolP- glucosyltransferase). [Uniprot/SWISSPROT;Acc:Q9Y673]	dolichyl-phosphate beta-glucosyltransferase activity
			oligosaccharyl transferase activity
			transferase activity, transferring glycosyl groups
1.54676	down	WAS protein homology region 2 domain containing 1 [RefSeq_peptide;Acc:NP_001073904]	actin binding
			hormone activity
			structural molecule activity
1.55809		Phosphatidylinositol N-acetylglucosaminyltransferase subunit H (EC 2.4.1.198) (Phosphatidylinositol-glycan biosynthesis class H protein) (PIG-H). [Uniprot/SWISSPROT;Acc:Q14442]	phosphatidylinositol N-acetylglucosaminyltransferase activity
			transferase activity, transferring glycosyl groups
1.55844	up	TP53-target gene 5 protein (TP53-inducible gene 5 protein). [Uniprot/SWISSPROT;Acc:Q9Y2B4]	molecular_function
1.56335		Zinc finger SWIM domain-containing protein 3. [Uniprot/SWISSPROT;Acc:Q96MP5]	metal ion binding
			zinc ion binding
1.57088		Forkhead box protein P2 (CAG repeat protein 44) (Trinucleotide repeat- containing gene 10 protein). [Uniprot/SWISSPROT;Acc:O15409]	metal ion binding
			nucleic acid binding
			protein homodimerization activity
			sequence-specific DNA binding
			transcription factor activity
			zinc ion binding
1.58045	down	Peroxisomal biogenesis factor 3 (Peroxin-3) (Peroxisomal assembly protein PEX3). [Uniprot/SWISSPROT;Acc:P56589]	protein binding
1.58115	up	Tetratricopeptide repeat protein 18 (TPR repeat protein 18). [Uniprot/SWISSPROT;Acc:Q5T0N1]	binding
1.59177		Transgelin-2 (SM22-alpha homolog). [Uniprot/SWISSPROT;Acc:P37802]	actin binding
			protein binding
1.59188		Zinc finger protein 384 (Nuclear matrix transcription factor 4) (Nuclear matrix protein 4) (CAG repeat protein 1) (CAS-interacting zinc finger protein) (Trinucleotide repeat-containing gene 1 protein). [Uniprot/SWISSPROT;Acc:Q8TF68]	DNA binding
			metal ion binding
			nucleic acid binding
			zinc ion binding
1.59763	down	Ubiquitin-conjugating enzyme E2 Q2 (EC 6.3.2.19) (Ubiquitin-protein ligase Q2) (Ubiquitin carrier protein Q2). [Uniprot/SWISSPROT;Acc:Q8WVN8]	ATP binding
			ligase activity
			nucleotide binding
			small conjugating protein ligase activity
			ubiquitin-protein ligase activity
1.59819	up	Serine/threonine-protein phosphatase with EF-hands 2 (EC 3.1.3.16) (PPEF-2). [Uniprot/SWISSPROT;Acc:O14830]	calcium ion binding
			hydrolase activity
			iron ion binding
			manganese ion binding

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.