MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	Class	description	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 993 to 1042 of 2667 in total

Ratio	Regulation	Class	description	Gene Ontology
1.40602	up	molecular function	GTP-binding protein SAR1a (COPII-associated small GTPase). [Uniprot/SWISSPROT;Acc:Q9NR31]	GTP binding
				GTPase activity
				nucleotide binding
1.40749		biological process	collagen, type XXVII, alpha 1 [RefSeq_peptide;Acc:NP_116277]	cell adhesion
				G-protein coupled receptor protein signaling pathway
				phosphate transport
		cellular component		collagen
				cytoplasm
				integral to membrane
		molecular function		dopamine receptor activity
				extracellular matrix structural constituent
				structural constituent of cell wall
				structural molecule activity
1.41851	down	biological process	Docking protein 5 (Downstream of tyrosine kinase 5) (IRS6) (Protein dok-5). [Uniprot/SWISSPROT;Acc:Q9P104]	MAPKKK cascade
				nervous system development
				transmembrane receptor protein tyrosine kinase signaling pathway
		molecular function		insulin receptor binding
				transmembrane receptor protein tyrosine kinase signaling protein activity
1.42215		biological process	Sodium-dependent serotonin transporter (5HT transporter) (5HTT). [Uniprot/SWISSPROT;Acc:P31645]	monoamine transport
				neurotransmitter transport
				neurotransmitter uptake
				serotonin transport
		cellular component		integral to plasma membrane
				membrane
		molecular function		monoamine transporter activity
				neurotransmitter:sodium symporter activity
				protein binding
				serotonin transporter activity
				serotonin:sodium symporter activity
				symporter activity
1.42264	up	biological process	RNA-binding protein 4 (RNA-binding motif protein 4) (RNA-binding motif protein 4a) (Lark homolog) (hLark). [Uniprot/SWISSPROT;Acc:Q9BWF3]	homoiothermy
				mRNA processing
				response to freezing
				RNA splicing
				translation
				type I hypersensitivity
		cellular component		cytoplasm
				intracellular
				nucleus
				ribosome
		molecular function		ice binding
				metal ion binding
				nucleic acid binding
				nucleotide binding
				RNA binding
				structural constituent of ribosome
				zinc ion binding
1.43088	down	biological process	Isopentenyl-diphosphate Delta-isomerase 2 (EC 5.3.3.2) (IPP isomerase 2) (Isopentenyl pyrophosphate isomerase 2) (IPPI2). [Uniprot/SWISSPROT;Acc:Q9BXS1]	carotenoid biosynthetic process
				cholesterol biosynthetic process
				isoprenoid biosynthetic process

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.