MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Regulation	description	Ratio	Gene Ontology	Class	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 993 to 1042 of 2667 in total

Regulation  : down

description	Ratio	Gene Ontology	Class
Speedy protein A (Speedy-1) (Spy1) (Rapid inducer of G2/M progression in oocytes A) (RINGO A) (hSpy/Ringo A). [Uniprot/SWISSPROT;Acc:Q5MJ70]	1.27696	protein phosphatase type 1 activity	molecular function
		regulation of progression through cell cycle	biological process
		response to DNA damage stimulus
T-box transcription factor TBX2 (T-box protein 2). [Uniprot/SWISSPROT;Acc:Q13207]	1.28356	cardiac muscle development
		cell aging
		heart morphogenesis
		homoiothermy
		ice binding	molecular function
		mammary gland development	biological process
		membrane	cellular component
		multicellular organismal development	biological process
		muscle cell fate determination
		negative regulation of transcription from RNA polymerase II promoter
		nucleoside transporter activity	molecular function
		nucleus	cellular component
		positive regulation of cell proliferation	biological process
		protein binding	molecular function
		regulation of transcription, DNA-dependent	biological process
		response to freezing
		sequence-specific DNA binding	molecular function
		transcription	biological process
		transcription factor activity	molecular function
		transcription factor complex	cellular component
		transcriptional repressor activity	molecular function
		transport	biological process
TBK1 binding protein 1 [RefSeq_peptide;Acc:NP_055541]	1.351	dopamine receptor activity	molecular function
		G-protein coupled receptor protein signaling pathway	biological process
		integral to membrane	cellular component
Tetraspanin-3 (Tspan-3) (Transmembrane 4 superfamily member 8) (Tetraspanin TM4-A). [Uniprot/SWISSPROT;Acc:O60637]	3.07625	cell motility	biological process
		cell proliferation
		integral to membrane	cellular component
		membrane
Threonyl-tRNA synthetase, mitochondrial precursor (EC 6.1.1.3) (Threonine--tRNA ligase) (ThrRS) (Threonyl-tRNA synthetase-like 1). [Uniprot/SWISSPROT;Acc:Q9BW92]	2.25955	aminoacyl-tRNA ligase activity	molecular function
		ATP binding
		cytoplasm	cellular component
		ligase activity	molecular function
		mitochondrion	cellular component
		nucleotide binding	molecular function
		threonine-tRNA ligase activity
		threonyl-tRNA aminoacylation	biological process
		translation
		tRNA aminoacylation for protein translation
Thrombospondin-4 precursor. [Uniprot/SWISSPROT;Acc:P35443]	3.05037	calcium ion binding	molecular function
		cell adhesion	biological process
		extracellular region	cellular component
		heparin binding	molecular function
		protein binding
		proteinaceous extracellular matrix	cellular component
		structural molecule activity	molecular function
		substrate-bound cell migration, cell extension	biological process

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.