MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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description	Ratio	Regulation	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 990 to 1039 of 2667 in total

description	Ratio	Regulation	Class	Gene Ontology
Guanine nucleotide-binding protein alpha-14 subunit (G-protein alpha subunit 14). [Uniprot/SWISSPROT;Acc:O95837]	2.44552	down	molecular function	signal transducer activity
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta 2 (Transducin beta chain 2) (G protein beta 2 subunit). [Uniprot/SWISSPROT;Acc:P62879]	3.54799		biological process	G-protein coupled receptor protein signaling pathway
				signal transduction
			molecular function	calcium channel regulator activity
				GTPase activity
				protein binding
				signal transducer activity
Guanylate cyclase soluble subunit beta-2 (EC 4.6.1.2) (GCS-beta-2). [Uniprot/SWISSPROT;Acc:O75343]	1.18489	up	biological process	cGMP biosynthetic process
				cyclic nucleotide biosynthetic process
				intracellular signaling cascade
			cellular component	cytoplasm
			molecular function	guanylate cyclase activity
				heme binding
				iron ion binding
				metal ion binding
				phosphorus-oxygen lyase activity
Guanylin precursor (Guanylate cyclase activator 2A) (Guanylate cyclase-activating protein 1) (Gap-I) [Contains: HMW-guanylin; Guanylin]. [Uniprot/SWISSPROT;Acc:Q02747]	1.1611	down	biological process	electron transport
				signal transduction
			cellular component	extracellular region
			molecular function	electron carrier activity
				enzyme activator activity
				guanylate cyclase activator activity
				hormone activity
Hematological and neurological expressed 1 protein (Androgen-regulated protein 2). [Uniprot/SWISSPROT;Acc:Q9UK76]	3.62109		cellular component	nucleus
Hermansky-Pudlak syndrome 3 protein. [Uniprot/SWISSPROT;Acc:Q969F9]	2.2939	up	biological process	organelle organization and biogenesis
				pigmentation
			cellular component	cytoplasm
Homeobox protein Hox-D3 (Hox-4A). [Uniprot/SWISSPROT;Acc:P31249]	1.27461	down	biological process	anatomical structure morphogenesis
				G-protein coupled receptor protein signaling pathway
				multicellular organismal development
				regulation of transcription, DNA-dependent
				thyroid gland development
			cellular component	integral to membrane
				nucleus
			molecular function	DNA binding
				galanin receptor activity
				sequence-specific DNA binding
				transcription factor activity
Homeobox protein Nkx-2.8 (Homeobox protein NK-2 homolog H). [Uniprot/SWISSPROT;Acc:O15522]	1.30407	up	biological process	axonogenesis
				multicellular organismal development
				regulation of transcription, DNA-dependent
				transcription from RNA polymerase II promoter
			cellular component	nucleus
			molecular function	RNA polymerase II transcription factor activity
				sequence-specific DNA binding
				transcription factor activity
Homeobox protein SIX4 (Sine oculis homeobox homolog 4). [Uniprot/SWISSPROT;Acc:Q9UIU6]	3.70292		biological process	anatomical structure development
				embryonic skeletal morphogenesis
				homoiothermy
				inner ear morphogenesis

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.