MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Regulation	Class	Ratio	Gene Ontology	Gene	description	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 951 to 1000 of 2667 in total

Regulation  : down
Class  : molecular function

Ratio	Gene Ontology	description
1.60746	nucleotide binding	Chromodomain-helicase-DNA-binding protein 6 (EC 3.6.1.-) (ATP- dependent helicase CHD6) (CHD-6) (Radiation-induced gene B protein). [Uniprot/SWISSPROT;Acc:Q8TD26]
	tetracycline:hydrogen antiporter activity
1.61347	calcium ion binding	Calmodulin-like protein 5 (Calmodulin-like skin protein). [Uniprot/SWISSPROT;Acc:Q9NZT1]
	protein binding
1.65835	GTP binding	Selenocysteine-specific elongation factor (Elongation factor sec) (Eukaryotic elongation factor, selenocysteine-tRNA-specific). [Uniprot/SWISSPROT;Acc:P57772]
	GTPase activity
	nucleotide binding
	translation elongation factor activity
	tRNA binding
1.683	exonuclease activity	Exosome complex exonuclease RRP44 (EC 3.1.13.-) (Ribosomal RNA- processing protein 44) (DIS3 protein homolog). [Uniprot/SWISSPROT;Acc:Q9Y2L1]
	GDP-dissociation stimulator activity
	hydrolase activity
	ribonuclease activity
	RNA binding
1.693	catalytic activity	CDK5 regulatory subunit associated protein 1-like 1 [RefSeq_peptide;Acc:NP_060244]
	iron-sulfur cluster binding
1.69658	beta-galactoside alpha-2,3-sialyltransferase activity	CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase (EC 2.4.99.-) (Beta-galactoside alpha-2,3-sialyltransferase) (Alpha 2,3-sialyltransferase IV) (Alpha 2,3-ST) (Gal-NAc6S) (STZ) (SIAT4-C) (ST3Gal III) (SAT-3) (ST-4). [Uniprot/SWISSPROT;Acc:Q11206]
	sialyltransferase activity
	transferase activity, transferring glycosyl groups
1.72628	methylated-DNA-[protein]-cysteine S-methyltransferase activity	Coiled-coil domain-containing protein 108. [Uniprot/SWISSPROT;Acc:Q6ZU64]
	structural molecule activity
1.72656	protein serine/threonine phosphatase activity	protein phosphatase 1, regulatory subunit 15B [RefSeq_peptide;Acc:NP_116222]
1.73211	ATP binding	Antigen KI-67. [Uniprot/SWISSPROT;Acc:P46013]
	nucleotide binding
	protein binding
1.75846	L-cystine transporter activity	Cystinosin. [Uniprot/SWISSPROT;Acc:O60931]
1.76583	aminopeptidase activity	leukocyte-derived arginine aminopeptidase [RefSeq_peptide;Acc:NP_071745]
	membrane alanyl aminopeptidase activity
	metallopeptidase activity
	N-terminal arginine aminopeptidase activity
	N-terminal lysine aminopeptidase activity
	zinc ion binding
1.76994	metal ion binding	ADAM 12 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 12) (Meltrin alpha). [Uniprot/SWISSPROT;Acc:O43184]
	metalloendopeptidase activity
	metallopeptidase activity
	protein binding
	zinc ion binding
1.80858	protein binding	Rhophilin-1 (GTP-Rho-binding protein 1). [Uniprot/SWISSPROT;Acc:Q8TCX5]
	small GTPase regulator activity
1.81557	ATP binding	Putative DNA helicase INO80 complex homolog 1 (EC 3.6.1.-) (hINO80). [Uniprot/SWISSPROT;Acc:Q9ULG1]
	DNA binding
	helicase activity
	hydrolase activity
	ice binding
	nucleic acid binding
	nucleotide binding
1.82311	growth factor activity	Fibroblast growth factor 5 precursor (FGF-5) (HBGF-5) (Smag-82). [Uniprot/SWISSPROT;Acc:P12034]
1.86204	metal ion binding	Zinc finger and SCAN domain-containing protein 4 (Zinc finger protein 494). [Uniprot/SWISSPROT;Acc:Q8NAM6]
	nucleic acid binding
	transcription factor activity

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.