MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

Navigation/Query Panel:
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description	Ratio	Regulation	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 950 to 999 of 2667 in total

description	Ratio	Regulation	Class	Gene Ontology
Golgin subfamily B member 1 (Giantin) (Macrogolgin) (372 kDa Golgi complex-associated protein) (GCP372). [Uniprot/SWISSPROT;Acc:Q14789]	1.45148	up	cellular component	nucleus
			molecular function	DNA binding
				protein binding
Growth/differentiation factor 2 precursor (GDF-2) (Bone morphogenetic protein 9) (BMP-9). [Uniprot/SWISSPROT;Acc:Q9UK05]	3.11758	down	biological process	growth
			cellular component	extracellular region
				extracellular space
			molecular function	cytokine activity
				growth factor activity
GTP-binding protein Rhes precursor (Ras homolog enriched in striatum) (Tumor endothelial marker 2). [Uniprot/SWISSPROT;Acc:Q96D21]	3.64872	up	biological process	intracellular protein transport
				locomotory behavior
				nucleocytoplasmic transport
				protein transport
				signal transduction
				small GTPase mediated signal transduction
			cellular component	cellular_component
				intracellular
				membrane
			molecular function	GTP binding
				GTPase activity
				nucleotide binding
				protein binding
GTP-binding protein SAR1a (COPII-associated small GTPase). [Uniprot/SWISSPROT;Acc:Q9NR31]	1.40602		biological process	ER to Golgi vesicle-mediated transport
				intracellular protein transport
				small GTPase mediated signal transduction
			cellular component	cytoplasm
				endoplasmic reticulum
				Golgi apparatus
				intracellular
			molecular function	GTP binding
				GTPase activity
				nucleotide binding
Guanine nucleotide-binding protein alpha-14 subunit (G-protein alpha subunit 14). [Uniprot/SWISSPROT;Acc:O95837]	2.44552	down	biological process	G-protein coupled receptor protein signaling pathway
				protein amino acid ADP-ribosylation
				signal transduction
			cellular component	heterotrimeric G-protein complex
				plasma membrane
			molecular function	GTP binding
				GTPase activity
				guanyl nucleotide binding
				nucleotide binding
				signal transducer activity
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta 2 (Transducin beta chain 2) (G protein beta 2 subunit). [Uniprot/SWISSPROT;Acc:P62879]	3.54799		biological process	G-protein coupled receptor protein signaling pathway
				signal transduction
			molecular function	calcium channel regulator activity
				GTPase activity
				protein binding
				signal transducer activity
Guanylate cyclase soluble subunit beta-2 (EC 4.6.1.2) (GCS-beta-2). [Uniprot/SWISSPROT;Acc:O75343]	1.18489	up	biological process	cGMP biosynthetic process
				cyclic nucleotide biosynthetic process
				intracellular signaling cascade

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.