MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

Navigation/Query Panel:
Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].

Regulation	description	Ratio	Class	Gene Ontology	Gene	Minimum Ratio	Accession	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 901 to 950 of 2667 in total

Regulation  : down

description	Ratio	Class	Gene Ontology
Selenocysteine-specific elongation factor (Elongation factor sec) (Eukaryotic elongation factor, selenocysteine-tRNA-specific). [Uniprot/SWISSPROT;Acc:P57772]	1.65835	molecular function	GTP binding
			GTPase activity
			nucleotide binding
			translation elongation factor activity
			tRNA binding
Serine/threonine-protein kinase VRK3 (EC 2.7.11.1) (Vaccinia-related kinase 3). [Uniprot/SWISSPROT;Acc:Q8IV63]	4.14557	biological process	protein amino acid phosphorylation
		cellular component	nucleus
		molecular function	ATP binding
			nucleotide binding
			protein kinase activity
			protein serine/threonine kinase activity
			transferase activity
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform (EC 3.1.3.16) (PP2A-beta). [Uniprot/SWISSPROT;Acc:P62714]	2.31699	biological process	protein amino acid dephosphorylation
		cellular component	cytoplasm
			protein phosphatase type 2A complex
		molecular function	hydrolase activity
			iron ion binding
			manganese ion binding
			metal ion binding
			phosphoprotein phosphatase activity
			protein binding
			protein phosphatase type 2A activity
SERTA domain-containing protein 3 (Replication protein-binding trans- activator) (RPA-binding trans-activator). [Uniprot/SWISSPROT;Acc:Q9UJW9]	2.83611	biological process	negative regulation of cell growth
			positive regulation of transcription
			regulation of transcription, DNA-dependent
			transcription
		cellular component	nucleus
		molecular function	protein binding
			transcriptional activator activity
Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) (Amino acid transporter ATB0+) (Solute carrier family 6 member 14). [Uniprot/SWISSPROT;Acc:Q9UN76]	1.40552	biological process	amino acid metabolic process
			amino acid transport
			dicarboxylic acid transport
			neurotransmitter transport
		cellular component	integral to plasma membrane
			membrane
		molecular function	amino acid transporter activity
			neurotransmitter:sodium symporter activity
			sodium:dicarboxylate symporter activity
			symporter activity
Sodium- and chloride-dependent transporter XTRP3 (Solute carrier family 6 member 20) (Neurotransmitter transporter rB21A homolog). [Uniprot/SWISSPROT;Acc:Q9NP91]	1.11083	biological process	neurotransmitter transport
		cellular component	integral to plasma membrane
			membrane
			plasma membrane
		molecular function	neurotransmitter:sodium symporter activity
			symporter activity
			transporter activity
Sodium-dependent serotonin transporter (5HT transporter) (5HTT). [Uniprot/SWISSPROT;Acc:P31645]	1.42215	biological process	monoamine transport
			neurotransmitter transport
			neurotransmitter uptake
			serotonin transport

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.