MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Regulation	description	Ratio	Class	Gene Ontology	Gene	Minimum Ratio	Accession	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 90 to 139 of 2667 in total

Regulation  : down

description	Ratio	Class	Gene Ontology
AP-3 complex subunit sigma-2 (Adapter-related protein complex 3 sigma- 2 subunit) (Sigma-adaptin 3b) (AP-3 complex sigma-3B subunit) (Sigma- 3B-adaptin). [Uniprot/SWISSPROT;Acc:P59780]	1.50284	biological process	intracellular protein transport
			protein complex assembly
			transport
			vesicle-mediated transport
		cellular component	cytoplasmic vesicle
			Golgi apparatus
			membrane
			membrane coat
		molecular function	protein binding
			protein transporter activity
Arylamine N-acetyltransferase 1 (EC 2.3.1.5) (Arylamide acetylase 1) (Monomorphic arylamine N-acetyltransferase) (MNAT) (N- acetyltransferase type 1) (NAT-1). [Uniprot/SWISSPROT;Acc:P18440]	3.00923	biological process	metabolic process
		cellular component	cytoplasm
		molecular function	acetyltransferase activity
			arylamine N-acetyltransferase activity
			transferase activity
Arylamine N-acetyltransferase 2 (EC 2.3.1.5) (Arylamide acetylase 2) (Polymorphic arylamine N-acetyltransferase) (PNAT) (N- acetyltransferase type 2) (NAT-2). [Uniprot/SWISSPROT;Acc:P11245]	4.69231	biological process	metabolic process
		cellular component	cytoplasm
		molecular function	acetyltransferase activity
			arylamine N-acetyltransferase activity
			transferase activity
AT-hook-containing transcription factor 1 (Embryonic large molecule derived from yolk sac). [Uniprot/SWISSPROT;Acc:Q8WYP5]	3.83977	biological process	multicellular organismal development
			regulation of transcription
			transcription
		cellular component	cytoplasm
			nuclear matrix
			nucleus
		molecular function	DNA binding
			transcription factor activity
Atlastin-2 (ADP-ribosylation factor-like protein 6-interacting protein 2). [Uniprot/SWISSPROT;Acc:Q8NHH9]	1.24964	biological process	immune response
		cellular component	integral to membrane
			membrane
		molecular function	GTP binding
			GTPase activity
			nucleotide binding
			protein binding
ATP-binding domain 1 family member B. [Uniprot/SWISSPROT;Acc:Q9H9Y4]	3.06659		ATP binding
			nucleotide binding
Bcl-2-interacting killer (Apoptosis inducer NBK) (BP4) (BIP1). [Uniprot/SWISSPROT;Acc:Q13323]	1.21871	biological process	apoptotic program
			induction of apoptosis
			regulation of apoptosis
		cellular component	integral to membrane
			membrane
			mitochondrial envelope
		molecular function	protein binding
Beta-defensin 2 precursor (BD-2) (hBD-2) (Defensin, beta 2) (Skin- antimicrobial peptide 1) (SAP1). [Uniprot/SWISSPROT;Acc:O15263]	1.51342	biological process	chemotaxis
			defense response
			defense response to bacterium
			G-protein coupled receptor protein signaling pathway
			immune response
		cellular component	extracellular region

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.