MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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description	Ratio	Regulation	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 90 to 139 of 2667 in total

description	Ratio	Regulation	Class	Gene Ontology
Aldehyde dehydrogenase, mitochondrial precursor (EC 1.2.1.3) (ALDH class 2) (ALDHI) (ALDH-E2). [Uniprot/SWISSPROT;Acc:P05091]	4.40797	down	biological process	metabolic process
				neuropeptide signaling pathway
			cellular component	mitochondrion
			molecular function	aldehyde dehydrogenase (NAD) activity
				aldehyde dehydrogenase [NAD(P)+] activity
				electron carrier activity
				neuropeptide hormone activity
				oxidoreductase activity
Amyloid beta A4 precursor protein-binding family A member 2 (Neuron- specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2) (Adapter protein X11beta). [Uniprot/SWISSPROT;Acc:Q99767]	2.49031	up	biological process	nervous system development
				protein transport
			molecular function	protein binding
Anion exchange protein 3 (Neuronal band 3-like protein) (Solute carrier family 4 member 3) (Cardiac/brain band 3-like protein) (CAE3/BAE3). [Uniprot/SWISSPROT;Acc:P48751]	2.88235	down	biological process	anion transport
			cellular component	integral to membrane
				integral to plasma membrane
				membrane
				membrane fraction
			molecular function	anion exchanger activity
				antiporter activity
				inorganic anion exchanger activity
Ankyrin repeat and SOCS box protein 12 (ASB-12). [Uniprot/SWISSPROT;Acc:Q8WXK4]	4.93372		biological process	intracellular signaling cascade
Antigen KI-67. [Uniprot/SWISSPROT;Acc:P46013]	1.73211			cell cycle
				cell proliferation
				meiosis
				regulation of progression through cell cycle
			cellular component	chromosome, pericentric region
				condensed chromosome
				cytoplasm
				nucleolus
				nucleus
			molecular function	ATP binding
				nucleotide binding
				protein binding
AP-3 complex subunit sigma-1 (Adapter-related protein complex 3 sigma- 1 subunit) (Sigma-adaptin 3a) (AP-3 complex sigma-3A subunit) (Sigma- 3A-adaptin) (Clathrin-associated/assembly/adapter protein, small 3). [Uniprot/SWISSPROT;Acc:Q92572]	4.07995	up	biological process	insulin receptor signaling pathway
				intracellular protein transport
				protein complex assembly
				transport
				vesicle-mediated transport
			cellular component	cytoplasmic vesicle
				Golgi apparatus
				membrane
				membrane coat
				membrane coat adaptor complex
				transport vesicle
			molecular function	protein binding
				protein transporter activity
				transporter activity
AP-3 complex subunit sigma-2 (Adapter-related protein complex 3 sigma- 2 subunit) (Sigma-adaptin 3b) (AP-3 complex sigma-3B subunit) (Sigma- 3B-adaptin). [Uniprot/SWISSPROT;Acc:P59780]	1.50284	down	biological process	intracellular protein transport
				protein complex assembly
				transport
				vesicle-mediated transport

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.