MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	Gene Ontology	description	Class	Gene	Minimum Ratio	Maximum Ratio	Accession

Results: HTML CSV LaTeX

Showing element 801 to 850 of 948 in total

Class  : biological process

Ratio	Regulation	Gene Ontology	description
3.52215	down	response to stimulus	Olfactory receptor 4L1 (Olfactory receptor OR14-28). [Uniprot/SWISSPROT;Acc:Q8NH43]
		sensory perception of smell
		signal transduction
3.54414	up	cell-cell signaling	Toll-interacting protein. [Uniprot/SWISSPROT;Acc:Q9H0E2]
		immune response
		inflammatory response
		intracellular signaling cascade
		leukocyte activation
		phosphorylation
3.54799	down	G-protein coupled receptor protein signaling pathway	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta 2 (Transducin beta chain 2) (G protein beta 2 subunit). [Uniprot/SWISSPROT;Acc:P62879]
		signal transduction
3.54928		glycerol metabolic process	Glycerophosphodiester phosphodiesterase domain-containing protein 5 (EC 3.1.-.-) (Glycerophosphodiester phosphodiesterase 2). [Uniprot/SWISSPROT;Acc:Q8WTR4]
3.64872	up	intracellular protein transport	GTP-binding protein Rhes precursor (Ras homolog enriched in striatum) (Tumor endothelial marker 2). [Uniprot/SWISSPROT;Acc:Q96D21]
		locomotory behavior
		nucleocytoplasmic transport
		protein transport
		signal transduction
		small GTPase mediated signal transduction
3.70292		anatomical structure development	Homeobox protein SIX4 (Sine oculis homeobox homolog 4). [Uniprot/SWISSPROT;Acc:Q9UIU6]
		embryonic skeletal morphogenesis
		homoiothermy
		inner ear morphogenesis
		multicellular organismal development
		myoblast migration
		positive regulation of transcription
		regulation of transcription, DNA-dependent
		response to freezing
		striated muscle development
		thymus development
3.71868	down	translation	Protein pelota homolog. [Uniprot/SWISSPROT;Acc:Q9BRX2]
3.74971	up	response to oxidative stress	Glutathione peroxidase 6 precursor (EC 1.11.1.9). [Uniprot/SWISSPROT;Acc:P59796]
3.81736		cell cycle	Transcription factor E2F3 (E2F-3). [Uniprot/SWISSPROT;Acc:O00716]
		homoiothermy
		regulation of progression through cell cycle
		regulation of transcription, DNA-dependent
		response to freezing
		transcription
		transcription initiation from RNA polymerase II promoter
3.83977	down	multicellular organismal development	AT-hook-containing transcription factor 1 (Embryonic large molecule derived from yolk sac). [Uniprot/SWISSPROT;Acc:Q8WYP5]
		regulation of transcription
		transcription
3.89584	up	cell communication	Kremen protein 1 precursor (Kringle-containing protein marking the eye and the nose) (Kringle domain-containing transmembrane protein 1) (Dickkopf receptor). [Uniprot/SWISSPROT;Acc:Q96MU8]
		Wnt receptor signaling pathway
3.99682	down	cell adhesion	Contactin-3 precursor (Brain-derived immunoglobulin superfamily protein 1) (BIG-1) (Plasmacytoma-associated neuronal glycoprotein). [Uniprot/SWISSPROT;Acc:Q9P232]
		protein amino acid phosphorylation
4.03725	up	dephosphorylation	Receptor-type tyrosine-protein phosphatase epsilon precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase epsilon) (R-PTP-epsilon). [Uniprot/SWISSPROT;Acc:P23469]
		protein amino acid dephosphorylation
		transmembrane receptor protein tyrosine phosphatase signaling pathway
4.04651		mitotic spindle organization and biogenesis	Sad1/unc-84-like protein 2 (Rab5-interacting protein) (Rab5IP). [Uniprot/SWISSPROT;Acc:Q9UH99]
		nuclear membrane organization and biogenesis

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.