MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Regulation	description	Ratio	Class	Gene Ontology	Gene	Minimum Ratio	Accession	Maximum Ratio

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Showing element 790 to 839 of 2667 in total

Regulation  : down

description	Ratio	Class	Gene Ontology
Prostaglandin G/H synthase 2 precursor (EC 1.14.99.1) (Cyclooxygenase- 2) (COX-2) (Prostaglandin-endoperoxide synthase 2) (Prostaglandin H2 synthase 2) (PGH synthase 2) (PGHS-2) (PHS II). [Uniprot/SWISSPROT;Acc:P35354]	1.18096	cellular component	nucleus
			protein complex
		molecular function	heme binding
			iron ion binding
			metal ion binding
			oxidoreductase activity
			oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
			peroxidase activity
			prostaglandin-endoperoxide synthase activity
			protein binding
Protein CWC15 homolog. [Uniprot/SWISSPROT;Acc:Q9P013]	1.25205	biological process	nuclear mRNA splicing, via spliceosome
			RNA splicing
			SRP-dependent cotranslational protein targeting to membrane
		cellular component	membrane
			nucleus
			spliceosome
		molecular function	7S RNA binding
			GTP binding
			RNA binding
Protein Jade-1 (PHD finger protein 17). [Uniprot/SWISSPROT;Acc:Q6IE81]	6.3909	biological process	apoptosis
			intracellular signaling cascade
			negative regulation of cell growth
			regulation of transcription, DNA-dependent
			response to stress
			transcription
		cellular component	cytoplasm
			nucleus
		molecular function	metal ion binding
			protein binding
			zinc ion binding
Protein kinase C-binding protein NELL2 precursor (NEL-like protein 2) (Nel-related protein 2). [Uniprot/SWISSPROT;Acc:Q99435]	1.13541	biological process	blood coagulation
			cell adhesion
			regulation of growth
		cellular component	extracellular region
			membrane
		molecular function	calcium ion binding
			protein binding
			structural molecule activity
			transmembrane receptor activity
Protein pelota homolog. [Uniprot/SWISSPROT;Acc:Q9BRX2]	3.71868	biological process	translation
		cellular component	nucleus
		molecular function	protein binding
protein phosphatase 1, regulatory subunit 15B [RefSeq_peptide;Acc:NP_116222]	1.72656	biological process	ER overload response
			response to hydrogen peroxide
			response to oxidative stress
		cellular component	protein phosphatase type 1 complex
		molecular function	protein serine/threonine phosphatase activity
Protein RER1. [Uniprot/SWISSPROT;Acc:O15258]	1.11956	biological process	retrograde vesicle-mediated transport, Golgi to ER
		cellular component	Golgi apparatus
			integral to Golgi membrane

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.