MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	Gene Ontology	Class	description	Gene	Minimum Ratio	Accession	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 751 to 800 of 2667 in total

Ratio	Regulation	Gene Ontology	Class	description
1.30142	down	sensory perception of sound	biological process	Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (CD333 antigen). [Uniprot/SWISSPROT;Acc:P22607]
		skeletal development
		transferase activity	molecular function
1.30207		AP-1 adaptor complex	cellular component	Low density lipoprotein receptor adapter protein 1 (Autosomal recessive hypercholesterolemia protein). [Uniprot/SWISSPROT;Acc:Q5SW96]
		AP-2 adaptor complex
		basal plasma membrane
		cholesterol homeostasis	biological process
		cholesterol metabolic process
		clathrin binding	molecular function
		cytoplasm	cellular component
		cytosol
		early endosome
		endocytosis	biological process
		lipid metabolic process
		phosphotyrosine binding	molecular function
		positive regulation of receptor mediated endocytosis	biological process
		protein binding	molecular function
		protein binding, bridging
		protein C-terminus binding
		receptor signaling complex scaffold activity
		regulation of protein binding	biological process
		steroid metabolic process
		transport accessory protein activity	molecular function
1.30407	up	axonogenesis	biological process	Homeobox protein Nkx-2.8 (Homeobox protein NK-2 homolog H). [Uniprot/SWISSPROT;Acc:O15522]
		multicellular organismal development
		nucleus	cellular component
		regulation of transcription, DNA-dependent	biological process
		RNA polymerase II transcription factor activity	molecular function
		sequence-specific DNA binding
		transcription factor activity
		transcription from RNA polymerase II promoter	biological process
1.30802	down	ATP binding	molecular function	Canalicular multispecific organic anion transporter 2 (ATP-binding cassette sub-family C member 3) (Multidrug resistance-associated protein 3) (Multi-specific organic anion transporter-D) (MOAT-D). [Uniprot/SWISSPROT;Acc:O15438]
		ATPase activity
		ATPase activity, coupled to transmembrane movement of substances
		integral to membrane	cellular component
		integral to plasma membrane
		membrane
		membrane fraction
		nucleoside-triphosphatase activity	molecular function
		nucleotide binding
		organic anion transporter activity
		transport	biological process
		transporter activity	molecular function
1.30869		cell cycle	biological process	E3 ubiquitin-protein ligase CHFR (EC 6.3.2.-) (Checkpoint with forkhead and RING finger domains protein) (RING finger protein 196). [Uniprot/SWISSPROT;Acc:Q96EP1]
		cell division
		cellular_component	cellular component
		ligase activity	molecular function
		metal ion binding
		mitosis	biological process
		mitotic cell cycle

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.