MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	description	Regulation	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 751 to 800 of 2667 in total

Ratio	description	Regulation	Class	Gene Ontology
1.30142	Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (CD333 antigen). [Uniprot/SWISSPROT;Acc:P22607]	down	molecular function	protein-tyrosine kinase activity
				receptor activity
				transferase activity
1.30207	Low density lipoprotein receptor adapter protein 1 (Autosomal recessive hypercholesterolemia protein). [Uniprot/SWISSPROT;Acc:Q5SW96]		biological process	cholesterol homeostasis
				cholesterol metabolic process
				endocytosis
				lipid metabolic process
				positive regulation of receptor mediated endocytosis
				regulation of protein binding
				steroid metabolic process
			cellular component	AP-1 adaptor complex
				AP-2 adaptor complex
				basal plasma membrane
				cytoplasm
				cytosol
				early endosome
			molecular function	clathrin binding
				phosphotyrosine binding
				protein binding
				protein binding, bridging
				protein C-terminus binding
				receptor signaling complex scaffold activity
				transport accessory protein activity
1.30407	Homeobox protein Nkx-2.8 (Homeobox protein NK-2 homolog H). [Uniprot/SWISSPROT;Acc:O15522]	up	biological process	axonogenesis
				multicellular organismal development
				regulation of transcription, DNA-dependent
				transcription from RNA polymerase II promoter
			cellular component	nucleus
			molecular function	RNA polymerase II transcription factor activity
				sequence-specific DNA binding
				transcription factor activity
1.30802	Canalicular multispecific organic anion transporter 2 (ATP-binding cassette sub-family C member 3) (Multidrug resistance-associated protein 3) (Multi-specific organic anion transporter-D) (MOAT-D). [Uniprot/SWISSPROT;Acc:O15438]	down	biological process	transport
			cellular component	integral to membrane
				integral to plasma membrane
				membrane
				membrane fraction
			molecular function	ATP binding
				ATPase activity
				ATPase activity, coupled to transmembrane movement of substances
				nucleoside-triphosphatase activity
				nucleotide binding
				organic anion transporter activity
				transporter activity
1.30869	E3 ubiquitin-protein ligase CHFR (EC 6.3.2.-) (Checkpoint with forkhead and RING finger domains protein) (RING finger protein 196). [Uniprot/SWISSPROT;Acc:Q96EP1]		biological process	cell cycle
				cell division
				mitosis
				mitotic cell cycle
				mitotic checkpoint
				protein polyubiquitination
				ubiquitin cycle

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.