MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	description	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 701 to 750 of 2667 in total

Ratio	Regulation	description	Class	Gene Ontology
1.29238	up	Coiled-coil and C2 domain-containing protein 1B. [Uniprot/SWISSPROT;Acc:Q5T0F9]	molecular function	oxidoreductase activity
1.29424	down	Calcyphosin-2 (Calcyphosine-2). [Uniprot/SWISSPROT;Acc:Q9BXY5]	biological process	ciliary or flagellar motility
			cellular component	flagellin-based flagellum
			molecular function	calcium ion binding
1.2984		nucleolar and spindle associated protein 1 isoform 2 [RefSeq_peptide;Acc:NP_060924]	biological process	cytokinesis after mitosis
				establishment of mitotic spindle localization
				mitotic chromosome condensation
				positive regulation of mitosis
			cellular component	nucleolus
				spindle microtubule
			molecular function	microtubule binding
1.29952		Melanoma-associated antigen C2 (MAGE-C2 antigen) (MAGE-E1 antigen) (Hepatocellular carcinoma-associated antigen 587) (Cancer-testis antigen 10) (CT10). [Uniprot/SWISSPROT;Acc:Q9UBF1]	biological process	regulation of progression through cell cycle
			cellular component	cytoplasm
				nucleus
1.30082		CCR4-NOT transcription complex subunit 2 (CCR4-associated factor 2). [Uniprot/SWISSPROT;Acc:Q9NZN8]	biological process	regulation of global transcription from RNA polymerase II promoter
				regulation of transcription
				regulation of transcription, DNA-dependent
			cellular component	cytoplasm
				nucleus
			molecular function	RNA polymerase II transcription mediator activity
				transcription regulator activity
1.30142		Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (CD333 antigen). [Uniprot/SWISSPROT;Acc:P22607]	biological process	cell growth
				fibroblast growth factor receptor signaling pathway
				forebrain development
				hair cell differentiation
				inner ear development
				JAK-STAT cascade
				MAPKKK cascade
				morphogenesis of an epithelium
				negative regulation of epithelial cell proliferation
				positive regulation of apoptosis
				positive regulation of cell differentiation
				positive regulation of peptidyl-tyrosine phosphorylation
				positive regulation of protein ubiquitination
				protein amino acid phosphorylation
				sensory perception of sound
				skeletal development
			cellular component	integral to membrane
				integral to plasma membrane
				internal side of plasma membrane
				lysosome
				membrane
				perinuclear region of cytoplasm
			molecular function	ATP binding
				fibroblast growth factor receptor activity
				identical protein binding
				interleukin-1 receptor activity
				nucleotide binding
				protein kinase activity
				protein serine/threonine kinase activity

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.