MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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description	Ratio	Regulation	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 693 to 742 of 2667 in total

description	Ratio	Regulation	Class	Gene Ontology
Dehydrogenase/reductase SDR family member 1 (EC 1.1.-.-). [Uniprot/SWISSPROT;Acc:Q96LJ7]	1.25729	up	biological process	enterobactin biosynthetic process
				metabolic process
			cellular component	endoplasmic reticulum
				mitochondrial inner membrane
			molecular function	2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity
				oxidoreductase activity
Deoxyribonuclease-2-alpha precursor (EC 3.1.22.1) (Deoxyribonuclease II alpha) (DNase II alpha) (Acid DNase) (Lysosomal DNase II) (R31240_2). [Uniprot/SWISSPROT;Acc:O00115]	1.19545		biological process	apoptosis
				DNA catabolic process
				DNA metabolic process
				erythrocyte differentiation
				multicellular organismal development
			cellular component	extracellular region
				lysosome
			molecular function	deoxyribonuclease II activity
				DNA binding
				endodeoxyribonuclease activity
				endonuclease activity
				hormone activity
				hydrolase activity
				protein binding
Diacylglycerol O-acyltransferase 2 (EC 2.3.1.20) (Diglyceride acyltransferase 2). [Uniprot/SWISSPROT;Acc:Q96PD7]	3.31364		biological process	glycerol metabolic process
				lipid biosynthetic process
				lipid metabolic process
				triacylglycerol biosynthetic process
			cellular component	endoplasmic reticulum
				integral to membrane
				membrane
				membrane fraction
			molecular function	2-acylglycerol O-acyltransferase activity
				acyltransferase activity
				diacylglycerol O-acyltransferase activity
				transferase activity
Disco-interacting protein 2 homolog C. [Uniprot/SWISSPROT;Acc:Q9Y2E4]	1.21384	down	biological process	metabolic process
			cellular component	nucleus
			molecular function	catalytic activity
				transcription factor binding
DNA-directed RNA polymerase III subunit RPC8 (RNA polymerase III subunit C8) (DNA-directed RNA polymerase III subunit H) (DNA-directed RNA polymerase III subunit 22.9 kDa polypeptide). [Uniprot/SWISSPROT;Acc:Q9Y535]	6.56408		biological process	transcription
				transcription from RNA polymerase III promoter
			cellular component	DNA-directed RNA polymerase III complex
				nucleoplasm
				nucleus
			molecular function	DNA-directed RNA polymerase activity
				protein binding
Docking protein 5 (Downstream of tyrosine kinase 5) (IRS6) (Protein dok-5). [Uniprot/SWISSPROT;Acc:Q9P104]	1.41851		biological process	MAPKKK cascade
				nervous system development
				transmembrane receptor protein tyrosine kinase signaling pathway
			molecular function	insulin receptor binding
				transmembrane receptor protein tyrosine kinase signaling protein activity
Dolichyl-phosphate beta-glucosyltransferase (EC 2.4.1.117) (DolP- glucosyltransferase). [Uniprot/SWISSPROT;Acc:Q9Y673]	1.54317	up	biological process	determination of left/right symmetry
				protein amino acid glycosylation

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.