MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Regulation	description	Ratio	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 693 to 742 of 2667 in total

Regulation  : down

description	Ratio	Class	Gene Ontology
Nucleoplasmin-2. [Uniprot/SWISSPROT;Acc:Q86SE8]	5.83544	cellular component	nucleus
		molecular function	histone binding
			nucleic acid binding
olfactomedin-like 2A [RefSeq_peptide;Acc:NP_872293]	3.66058	cellular component	extracellular matrix
			membrane
		molecular function	extracellular matrix binding
			latrotoxin receptor activity
			protein homodimerization activity
Olfactory receptor 4L1 (Olfactory receptor OR14-28). [Uniprot/SWISSPROT;Acc:Q8NH43]	3.52215	biological process	G-protein coupled receptor protein signaling pathway
			response to stimulus
			sensory perception of smell
			signal transduction
		cellular component	integral to membrane
			membrane
		molecular function	melanocortin receptor activity
			olfactory receptor activity
			receptor activity
			rhodopsin-like receptor activity
Orexigenic neuropeptide QRFP receptor (G-protein coupled receptor 103) (SP9155) (AQ27). [Uniprot/SWISSPROT;Acc:Q96P65]	1.36911	biological process	G-protein coupled receptor protein signaling pathway
			signal transduction
		cellular component	integral to membrane
			membrane
		molecular function	bombesin receptor activity
			metabotropic glutamate, GABA-B-like receptor activity
			neuropeptide receptor activity
			neuropeptide Y receptor activity
			orexin receptor activity
			purinergic nucleotide receptor activity, G-protein coupled
			receptor activity
			rhodopsin-like receptor activity
Peroxisomal biogenesis factor 3 (Peroxin-3) (Peroxisomal assembly protein PEX3). [Uniprot/SWISSPROT;Acc:P56589]	1.58045	biological process	peroxisome organization and biogenesis
		cellular component	integral to peroxisomal membrane
			integral to plasma membrane
			membrane
			peroxisomal membrane
			peroxisome
		molecular function	protein binding
Phosphatidylinositol N-acetylglucosaminyltransferase subunit H (EC 2.4.1.198) (Phosphatidylinositol-glycan biosynthesis class H protein) (PIG-H). [Uniprot/SWISSPROT;Acc:Q14442]	1.55809	biological process	GPI anchor biosynthetic process
			protein modification process
		cellular component	cytoplasm
			endoplasmic reticulum
		molecular function	phosphatidylinositol N-acetylglucosaminyltransferase activity
			transferase activity, transferring glycosyl groups
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (EC 2.7.1.153) (PI3-kinase p110 subunit gamma) (PtdIns-3- kinase subunit p110) (PI3K) (PI3Kgamma) (p120-PI3K). [Uniprot/SWISSPROT;Acc:P48736]	5.23046	biological process	G-protein coupled receptor protein signaling pathway
			negative regulation of apoptosis
			phosphoinositide phosphorylation
			phosphoinositide-mediated signaling
			protein amino acid phosphorylation
		cellular component	phosphoinositide 3-kinase complex
		molecular function	1-phosphatidylinositol-3-kinase activity

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.