MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	description	Gene Ontology	Class	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 690 to 739 of 2667 in total

Ratio	Regulation	description	Gene Ontology	Class
1.29151	up	CLIP-associating protein 2 (Cytoplasmic linker-associated protein 2) (hOrbit2). [Uniprot/SWISSPROT;Acc:O75122]	establishment and/or maintenance of cell polarity	biological process
			galactoside 2-alpha-L-fucosyltransferase activity	molecular function
			Golgi apparatus	cellular component
			kinetochore microtubule
			microtubule binding	molecular function
			microtubule plus-end binding
			mitosis	biological process
			negative regulation of microtubule depolymerization
			protein binding	molecular function
			regulation of microtubule polymerization or depolymerization	biological process
1.29238		Coiled-coil and C2 domain-containing protein 1B. [Uniprot/SWISSPROT;Acc:Q5T0F9]	FAD binding	molecular function
			oxidoreductase activity
1.29424	down	Calcyphosin-2 (Calcyphosine-2). [Uniprot/SWISSPROT;Acc:Q9BXY5]	calcium ion binding
			ciliary or flagellar motility	biological process
			flagellin-based flagellum	cellular component
1.2984		nucleolar and spindle associated protein 1 isoform 2 [RefSeq_peptide;Acc:NP_060924]	cytokinesis after mitosis	biological process
			establishment of mitotic spindle localization
			microtubule binding	molecular function
			mitotic chromosome condensation	biological process
			nucleolus	cellular component
			positive regulation of mitosis	biological process
			spindle microtubule	cellular component
1.29952		Melanoma-associated antigen C2 (MAGE-C2 antigen) (MAGE-E1 antigen) (Hepatocellular carcinoma-associated antigen 587) (Cancer-testis antigen 10) (CT10). [Uniprot/SWISSPROT;Acc:Q9UBF1]	cytoplasm
			nucleus
			regulation of progression through cell cycle	biological process
1.30082		CCR4-NOT transcription complex subunit 2 (CCR4-associated factor 2). [Uniprot/SWISSPROT;Acc:Q9NZN8]	cytoplasm	cellular component
			nucleus
			regulation of global transcription from RNA polymerase II promoter	biological process
			regulation of transcription
			regulation of transcription, DNA-dependent
			RNA polymerase II transcription mediator activity	molecular function
			transcription regulator activity
1.30142		Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (CD333 antigen). [Uniprot/SWISSPROT;Acc:P22607]	ATP binding
			cell growth	biological process
			fibroblast growth factor receptor activity	molecular function
			fibroblast growth factor receptor signaling pathway	biological process
			forebrain development
			hair cell differentiation
			identical protein binding	molecular function
			inner ear development	biological process
			integral to membrane	cellular component
			integral to plasma membrane
			interleukin-1 receptor activity	molecular function
			internal side of plasma membrane	cellular component
			JAK-STAT cascade	biological process
			lysosome	cellular component
			MAPKKK cascade	biological process
			membrane	cellular component
			morphogenesis of an epithelium	biological process
			negative regulation of epithelial cell proliferation

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.