MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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description	Ratio	Regulation	Gene Ontology	Gene	Class	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 690 to 739 of 2667 in total

description	Ratio	Regulation	Gene Ontology	Class
Cytokine-like protein 1 precursor (Protein C17). [Uniprot/SWISSPROT;Acc:Q9NRR1]	1.44004	down	signal transduction	biological process
			soluble fraction	cellular component
DAZ-associated protein 2 (Deleted in azoospermia-associated protein 2). [Uniprot/SWISSPROT;Acc:Q15038]	4.90535		protein binding	molecular function
Dehydrogenase/reductase SDR family member 1 (EC 1.1.-.-). [Uniprot/SWISSPROT;Acc:Q96LJ7]	1.25729	up	2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity
			endoplasmic reticulum	cellular component
			enterobactin biosynthetic process	biological process
			metabolic process
			mitochondrial inner membrane	cellular component
			oxidoreductase activity	molecular function
Deoxyribonuclease-2-alpha precursor (EC 3.1.22.1) (Deoxyribonuclease II alpha) (DNase II alpha) (Acid DNase) (Lysosomal DNase II) (R31240_2). [Uniprot/SWISSPROT;Acc:O00115]	1.19545		apoptosis	biological process
			deoxyribonuclease II activity	molecular function
			DNA binding
			DNA catabolic process	biological process
			DNA metabolic process
			endodeoxyribonuclease activity	molecular function
			endonuclease activity
			erythrocyte differentiation	biological process
			extracellular region	cellular component
			hormone activity	molecular function
			hydrolase activity
			lysosome	cellular component
			multicellular organismal development	biological process
			protein binding	molecular function
Diacylglycerol O-acyltransferase 2 (EC 2.3.1.20) (Diglyceride acyltransferase 2). [Uniprot/SWISSPROT;Acc:Q96PD7]	3.31364		2-acylglycerol O-acyltransferase activity
			acyltransferase activity
			diacylglycerol O-acyltransferase activity
			endoplasmic reticulum	cellular component
			glycerol metabolic process	biological process
			integral to membrane	cellular component
			lipid biosynthetic process	biological process
			lipid metabolic process
			membrane	cellular component
			membrane fraction
			transferase activity	molecular function
			triacylglycerol biosynthetic process	biological process
Disco-interacting protein 2 homolog C. [Uniprot/SWISSPROT;Acc:Q9Y2E4]	1.21384	down	catalytic activity	molecular function
			metabolic process	biological process
			nucleus	cellular component
			transcription factor binding	molecular function
DNA-directed RNA polymerase III subunit RPC8 (RNA polymerase III subunit C8) (DNA-directed RNA polymerase III subunit H) (DNA-directed RNA polymerase III subunit 22.9 kDa polypeptide). [Uniprot/SWISSPROT;Acc:Q9Y535]	6.56408		DNA-directed RNA polymerase activity
			DNA-directed RNA polymerase III complex	cellular component
			nucleoplasm
			nucleus
			protein binding	molecular function
			transcription	biological process
			transcription from RNA polymerase III promoter
Docking protein 5 (Downstream of tyrosine kinase 5) (IRS6) (Protein dok-5). [Uniprot/SWISSPROT;Acc:Q9P104]	1.41851		insulin receptor binding	molecular function
			MAPKKK cascade	biological process
			nervous system development
			transmembrane receptor protein tyrosine kinase signaling pathway

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.