MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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description	Ratio	Regulation	Gene	Gene Ontology	Accession	Class	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 651 to 700 of 2667 in total

description	Ratio	Regulation	Gene Ontology	Class
Cystinosin. [Uniprot/SWISSPROT;Acc:O60931]	1.75846	down	membrane	cellular component
			transport	biological process
Cytochrome P450 26A1 (EC 1.14.-.-) (Retinoic acid-metabolizing cytochrome) (P450 retinoic acid-inactivating 1) (P450RAI) (hP450RAI) (Retinoic acid 4-hydroxylase). [Uniprot/SWISSPROT;Acc:O43174]	2.69364	up	anterior/posterior pattern formation
			central nervous system development
			electron transport
			endoplasmic reticulum	cellular component
			heme binding	molecular function
			iron ion binding
			membrane	cellular component
			metabolic process	biological process
			metal ion binding	molecular function
			microsome	cellular component
			monooxygenase activity	molecular function
			neural crest cell development	biological process
			oxygen binding	molecular function
			retinoic acid 4-hydroxylase activity
			retinoic acid metabolic process	biological process
			retinoic acid receptor signaling pathway
Cytochrome P450 2W1 (EC 1.14.14.-) (CYPIIW1). [Uniprot/SWISSPROT;Acc:Q8TAV3]	1.49264		electron transport
			endoplasmic reticulum	cellular component
			heme binding	molecular function
			iron ion binding
			membrane	cellular component
			metal ion binding	molecular function
			monooxygenase activity
			oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Cytokine receptor common beta chain precursor (GM-CSF/IL-3/IL-5 receptor common beta-chain) (CD131 antigen) (CDw131). [Uniprot/SWISSPROT;Acc:P32927]	1.18821	down	cytokine and chemokine mediated signaling pathway	biological process
			granulocyte macrophage colony-stimulating factor receptor complex	cellular component
			hematopoietin/interferon-class (D200-domain) cytokine receptor activity	molecular function
			integral to membrane	cellular component
			interleukin receptor activity	molecular function
			interleukin-3 receptor activity
			interleukin-5 receptor activity
			membrane	cellular component
			receptor activity	molecular function
			respiratory gaseous exchange	biological process
			signal transduction
Cytokine-like protein 1 precursor (Protein C17). [Uniprot/SWISSPROT;Acc:Q9NRR1]	1.44004		extracellular space	cellular component
			receptor binding	molecular function
			signal transduction	biological process
			soluble fraction	cellular component
DAZ-associated protein 2 (Deleted in azoospermia-associated protein 2). [Uniprot/SWISSPROT;Acc:Q15038]	4.90535		protein binding	molecular function
Dehydrogenase/reductase SDR family member 1 (EC 1.1.-.-). [Uniprot/SWISSPROT;Acc:Q96LJ7]	1.25729	up	2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity
			endoplasmic reticulum	cellular component
			enterobactin biosynthetic process	biological process
			metabolic process
			mitochondrial inner membrane	cellular component
			oxidoreductase activity	molecular function
Deoxyribonuclease-2-alpha precursor (EC 3.1.22.1) (Deoxyribonuclease II alpha) (DNase II alpha) (Acid DNase) (Lysosomal DNase II) (R31240_2). [Uniprot/SWISSPROT;Acc:O00115]	1.19545		apoptosis	biological process
			deoxyribonuclease II activity	molecular function

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.