MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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description	Ratio	Regulation	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 643 to 692 of 2667 in total

description	Ratio	Regulation	Class	Gene Ontology
Cysteine-rich hydrophobic domain 2 protein (BrX-like translocated in leukemia). [Uniprot/SWISSPROT;Acc:Q9UKJ5]	1.63639	up	cellular component	plasma membrane
			molecular function	molecular_function
Cystinosin. [Uniprot/SWISSPROT;Acc:O60931]	1.75846	down	biological process	amino acid metabolic process
				L-cystine transport
				transport
			cellular component	integral to membrane
				lysosomal membrane
				lysosome
				membrane
			molecular function	L-cystine transporter activity
Cytochrome P450 26A1 (EC 1.14.-.-) (Retinoic acid-metabolizing cytochrome) (P450 retinoic acid-inactivating 1) (P450RAI) (hP450RAI) (Retinoic acid 4-hydroxylase). [Uniprot/SWISSPROT;Acc:O43174]	2.69364	up	biological process	anterior/posterior pattern formation
				central nervous system development
				electron transport
				metabolic process
				neural crest cell development
				retinoic acid metabolic process
				retinoic acid receptor signaling pathway
			cellular component	endoplasmic reticulum
				membrane
				microsome
			molecular function	heme binding
				iron ion binding
				metal ion binding
				monooxygenase activity
				oxygen binding
				retinoic acid 4-hydroxylase activity
Cytochrome P450 2W1 (EC 1.14.14.-) (CYPIIW1). [Uniprot/SWISSPROT;Acc:Q8TAV3]	1.49264		biological process	electron transport
			cellular component	endoplasmic reticulum
				membrane
			molecular function	heme binding
				iron ion binding
				metal ion binding
				monooxygenase activity
				oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Cytokine receptor common beta chain precursor (GM-CSF/IL-3/IL-5 receptor common beta-chain) (CD131 antigen) (CDw131). [Uniprot/SWISSPROT;Acc:P32927]	1.18821	down	biological process	cytokine and chemokine mediated signaling pathway
				respiratory gaseous exchange
				signal transduction
			cellular component	granulocyte macrophage colony-stimulating factor receptor complex
				integral to membrane
				membrane
			molecular function	hematopoietin/interferon-class (D200-domain) cytokine receptor activity
				interleukin receptor activity
				interleukin-3 receptor activity
				interleukin-5 receptor activity
				receptor activity
Cytokine-like protein 1 precursor (Protein C17). [Uniprot/SWISSPROT;Acc:Q9NRR1]	1.44004		biological process	signal transduction
			cellular component	extracellular space
				soluble fraction
			molecular function	receptor binding
DAZ-associated protein 2 (Deleted in azoospermia-associated protein 2). [Uniprot/SWISSPROT;Acc:Q15038]	4.90535			protein binding

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.