MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Class	Ratio	Regulation	description	Gene	Gene Ontology	Minimum Ratio	Accession	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 643 to 692 of 2667 in total

Class  : biological process

Ratio	Regulation	description	Gene Ontology
2.10428	up	Transcription factor AP-1 (Activator protein 1) (AP1) (Proto-oncogene c-jun) (V-jun avian sarcoma virus 17 oncogene homolog) (p39). [Uniprot/SWISSPROT;Acc:P05412]	cellular process
			leading edge cell differentiation
			negative regulation of protein amino acid autophosphorylation
			positive regulation of transcription from RNA polymerase II promoter
			regulation of progression through cell cycle
			regulation of transcription
			regulation of transcription, DNA-dependent
2.12709	down	Ribonuclease P protein subunit p29 (EC 3.1.26.5) (hPOP4). [Uniprot/SWISSPROT;Acc:O95707]	rRNA processing
			tRNA processing
2.16131		39S ribosomal protein L15, mitochondrial precursor (L15mt) (MRP-L15). [Uniprot/SWISSPROT;Acc:Q9P015]	translation
2.20843	up	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes). [Uniprot/SWISSPROT;Acc:P07947]	glucose transport
			intracellular signaling cascade
			protein amino acid autophosphorylation
			protein amino acid phosphorylation
			protein modification process
2.25955	down	Threonyl-tRNA synthetase, mitochondrial precursor (EC 6.1.1.3) (Threonine--tRNA ligase) (ThrRS) (Threonyl-tRNA synthetase-like 1). [Uniprot/SWISSPROT;Acc:Q9BW92]	threonyl-tRNA aminoacylation
			translation
			tRNA aminoacylation for protein translation
2.2866	up	Protein phosphatase 1A (EC 3.1.3.16) (Protein phosphatase 2C isoform alpha) (PP2C-alpha) (IA). [Uniprot/SWISSPROT;Acc:P35813]	positive regulation of I-kappaB kinase/NF-kappaB cascade
			protein amino acid dephosphorylation
2.29381		Ataxin-7 (Spinocerebellar ataxia type 7 protein). [Uniprot/SWISSPROT;Acc:O15265]	cell death
			nuclear organization and biogenesis
			visual perception
2.2939		Hermansky-Pudlak syndrome 3 protein. [Uniprot/SWISSPROT;Acc:Q969F9]	organelle organization and biogenesis
			pigmentation
2.31039		STAGA complex 65 subunit gamma (STAF65gamma) (SPTF-associated factor 65 gamma) (Suppressor of Ty 7-like) (Adenocarcinoma antigen ART1). [Uniprot/SWISSPROT;Acc:O94864]	maintenance of protein localization in nucleus
			regulation of transcription, DNA-dependent
			transcription
2.31699	down	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform (EC 3.1.3.16) (PP2A-beta). [Uniprot/SWISSPROT;Acc:P62714]	protein amino acid dephosphorylation
2.33107		F-box only protein 15. [Uniprot/SWISSPROT;Acc:Q8NCQ5]	ubiquitin cycle
2.43098	up	Oxysterol-binding protein-related protein 2 (OSBP-related protein 2) (ORP-2). [Uniprot/SWISSPROT;Acc:Q9H1P3]	lipid transport
			steroid metabolic process
2.44552	down	Guanine nucleotide-binding protein alpha-14 subunit (G-protein alpha subunit 14). [Uniprot/SWISSPROT;Acc:O95837]	G-protein coupled receptor protein signaling pathway
			protein amino acid ADP-ribosylation
			signal transduction
2.45383		40S ribosomal protein S2 (S4) (LLRep3 protein). [Uniprot/SWISSPROT;Acc:P15880]	translation
2.45764	up	zinc transporter like 2 [RefSeq_peptide;Acc:NP_598003]	cation transport
			zinc ion transport
2.45875		ADAMTS-19 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 19) (ADAM-TS 19) (ADAM-TS19). [Uniprot/SWISSPROT;Acc:Q8TE59]	proteolysis
2.48474		BET1 homolog (Golgi vesicular membrane-trafficking protein p18) (hBET1). [Uniprot/SWISSPROT;Acc:O15155]	ER to Golgi vesicle-mediated transport
			protein transport
2.49031		Amyloid beta A4 precursor protein-binding family A member 2 (Neuron- specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2) (Adapter protein X11beta). [Uniprot/SWISSPROT;Acc:Q99767]	nervous system development
			protein transport
2.4954		OMA1 homolog, zinc metallopeptidase [RefSeq_peptide;Acc:NP_660286]	proteolysis
2.51088	down	Epididymal-specific lipocalin-12 precursor. [Uniprot/SWISSPROT;Acc:Q6JVE5]	lipid metabolic process
			transport
2.54508	up	Neuroligin-2 precursor. [Uniprot/SWISSPROT;Acc:Q8NFZ4]	cell adhesion
			cell-cell adhesion
			intercellular junction maintenance
			synaptogenesis

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.