MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Regulation	description	Ratio	Class	Gene Ontology	Gene	Minimum Ratio	Accession	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 640 to 689 of 2667 in total

Regulation  : down

description	Ratio	Class	Gene Ontology
Nuclear factor of activated T-cells, cytoplasmic 3 (NF-ATc3) (NFATc3) (T cell transcription factor NFAT4) (NF-AT4) (NFATx). [Uniprot/SWISSPROT;Acc:Q12968]	5.32612	cellular component	cytoplasm
			nucleus
		molecular function	protein binding
			transcription coactivator activity
			transcription factor activity
Nuclear pore complex protein Nup153 (Nucleoporin Nup153) (153 kDa nucleoporin). [Uniprot/SWISSPROT;Acc:P49790]	1.48389	biological process	ATP synthesis coupled proton transport
			intracellular protein transport across a membrane
			mRNA transport
			protein transport
		cellular component	intracellular
			nuclear pore
			nucleus
			proton-transporting two-sector ATPase complex
		molecular function	ATP binding
			DNA binding
			hydrogen ion transporting ATP synthase activity, rotational mechanism
			hydrogen ion transporting ATPase activity, rotational mechanism
			metal ion binding
			protein binding
			transporter activity
			zinc ion binding
Nuclear receptor ROR-alpha (Retinoid-related orphan receptor-alpha) (Nuclear receptor RZR-alpha). [Uniprot/SWISSPROT;Acc:P35398]	1.98137	biological process	regulation of transcription, DNA-dependent
			signal transduction
			transcription
		cellular component	nucleus
		molecular function	DNA binding
			ligand-dependent nuclear receptor activity
			metal ion binding
			protein binding
			sequence-specific DNA binding
			steroid hormone receptor activity
			thyroid hormone receptor activity
			transcription factor activity
			zinc ion binding
nucleolar and spindle associated protein 1 isoform 2 [RefSeq_peptide;Acc:NP_060924]	1.2984	biological process	cytokinesis after mitosis
			establishment of mitotic spindle localization
			mitotic chromosome condensation
			positive regulation of mitosis
		cellular component	nucleolus
			spindle microtubule
		molecular function	microtubule binding
Nucleolar preribosomal-associated protein 1 (Fragment). [Uniprot/SWISSPROT;Acc:O60287]	1.36755	biological process	biological_process
		cellular component	nucleolus
			nucleus
		molecular function	molecular_function
Nucleoplasmin-2. [Uniprot/SWISSPROT;Acc:Q86SE8]	5.83544	biological process	chromatin remodeling
			embryonic development
			oocyte differentiation
			positive regulation of meiosis
			regulation of exit from mitosis

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.