MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	description	Gene Ontology	Class	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 601 to 650 of 2667 in total

Ratio	Regulation	description	Gene Ontology	Class
1.25808	up	Chromodomain-helicase-DNA-binding protein 7 (EC 3.6.1.-) (ATP- dependent helicase CHD7) (CHD-7). [Uniprot/SWISSPROT;Acc:Q9P2D1]	transcription	biological process
1.2734		Neurexin-2-alpha precursor (Neurexin II-alpha). [Uniprot/SWISSPROT;Acc:Q9P2S2]	calcium channel regulator activity	molecular function
			calcium ion binding
			cell adhesion	biological process
			integral to membrane	cellular component
			membrane
			neurotransmitter secretion	biological process
			protein binding	molecular function
			synaptic transmission	biological process
			synaptogenesis
1.27461	down	Homeobox protein Hox-D3 (Hox-4A). [Uniprot/SWISSPROT;Acc:P31249]	anatomical structure morphogenesis
			DNA binding	molecular function
			G-protein coupled receptor protein signaling pathway	biological process
			galanin receptor activity	molecular function
			integral to membrane	cellular component
			multicellular organismal development	biological process
			nucleus	cellular component
			regulation of transcription, DNA-dependent	biological process
			sequence-specific DNA binding	molecular function
			thyroid gland development	biological process
			transcription factor activity	molecular function
1.27516	up	Uncharacterized protein C16orf48. [Uniprot/SWISSPROT;Acc:Q9H0I2]	microtubule cytoskeleton	cellular component
1.27696	down	Speedy protein A (Speedy-1) (Spy1) (Rapid inducer of G2/M progression in oocytes A) (RINGO A) (hSpy/Ringo A). [Uniprot/SWISSPROT;Acc:Q5MJ70]	cell cycle	biological process
			G1/S transition of mitotic cell cycle
			multicellular organismal development
			nucleus	cellular component
			positive regulation of cell proliferation	biological process
			positive regulation of cyclin-dependent protein kinase activity
			protein amino acid dephosphorylation
			protein binding	molecular function
			protein kinase binding
			protein phosphatase type 1 activity
			regulation of progression through cell cycle	biological process
			response to DNA damage stimulus
1.27802		Melanoma-associated antigen B2 (MAGE-B2 antigen) (DSS-AHC critical interval MAGE superfamily 6) (DAM6) (MAGE XP-2). [Uniprot/SWISSPROT;Acc:O15479]	homoiothermy
			ice binding	molecular function
			protein binding
			response to freezing	biological process
1.28319	up	Autophagy-related protein 10 (APG10-like). [Uniprot/SWISSPROT;Acc:Q9H0Y0]	autophagy
			cytoplasm	cellular component
			intracellular
			positive regulation of protein modification	biological process
			protein amino acid lipidation
			protein binding	molecular function
			protein transport	biological process
			ubiquitin cycle
1.28356	down	T-box transcription factor TBX2 (T-box protein 2). [Uniprot/SWISSPROT;Acc:Q13207]	cardiac muscle development
			cell aging
			heart morphogenesis
			homoiothermy

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.