MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Regulation	description	Ratio	Class	Gene Ontology	Gene	Minimum Ratio	Accession	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 551 to 600 of 2667 in total

Regulation  : down

description	Ratio	Class	Gene Ontology
Low density lipoprotein receptor adapter protein 1 (Autosomal recessive hypercholesterolemia protein). [Uniprot/SWISSPROT;Acc:Q5SW96]	1.30207	biological process	cholesterol homeostasis
			cholesterol metabolic process
			endocytosis
			lipid metabolic process
			positive regulation of receptor mediated endocytosis
			regulation of protein binding
			steroid metabolic process
		cellular component	AP-1 adaptor complex
			AP-2 adaptor complex
			basal plasma membrane
			cytoplasm
			cytosol
			early endosome
		molecular function	clathrin binding
			phosphotyrosine binding
			protein binding
			protein binding, bridging
			protein C-terminus binding
			receptor signaling complex scaffold activity
			transport accessory protein activity
Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA (EC 3.2.1.113) (Processing alpha-1,2-mannosidase IA) (Alpha-1,2-mannosidase IA) (Mannosidase alpha class 1A member 1) (Man(9)-alpha-mannosidase) (Man9-mannosidase). [Uniprot/SWISSPROT;Acc:P33908]	1.24361	biological process	metabolic process
			protein amino acid glycosylation
		cellular component	endoplasmic reticulum
			ER-Golgi intermediate compartment
			Golgi apparatus
			integral to membrane
			membrane
			membrane fraction
		molecular function	calcium ion binding
			hydrolase activity, acting on glycosyl bonds
			mannosidase activity
			mannosyl-oligosaccharide 1,2-alpha-mannosidase activity
MAP7 domain containing 1 [RefSeq_peptide;Acc:NP_060537]	7.45006	biological process	G-protein coupled receptor protein signaling pathway
		cellular component	integral to membrane
		molecular function	histamine receptor activity
			structural constituent of cell wall
Melanoma-associated antigen B2 (MAGE-B2 antigen) (DSS-AHC critical interval MAGE superfamily 6) (DAM6) (MAGE XP-2). [Uniprot/SWISSPROT;Acc:O15479]	1.27802	biological process	homoiothermy
			response to freezing
		molecular function	ice binding
			protein binding
Melanoma-associated antigen C2 (MAGE-C2 antigen) (MAGE-E1 antigen) (Hepatocellular carcinoma-associated antigen 587) (Cancer-testis antigen 10) (CT10). [Uniprot/SWISSPROT;Acc:Q9UBF1]	1.29952	biological process	regulation of progression through cell cycle
		cellular component	cytoplasm
			nucleus
Myelin transcription factor 1-like protein (MyT1L protein) (MyT1-L). [Uniprot/SWISSPROT;Acc:Q9UL68]	2.58329	biological process	cell differentiation
			multicellular organismal development
			nervous system development
			regulation of transcription, DNA-dependent
			transcription
		cellular component	nucleus
		molecular function	calcium ion binding

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.