MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Class	Ratio	Regulation	description	Gene	Gene Ontology	Minimum Ratio	Accession	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 551 to 600 of 2667 in total

Class  : biological process

Ratio	Regulation	description	Gene Ontology
1.683	down	Exosome complex exonuclease RRP44 (EC 3.1.13.-) (Ribosomal RNA- processing protein 44) (DIS3 protein homolog). [Uniprot/SWISSPROT;Acc:Q9Y2L1]	rRNA processing
1.693		CDK5 regulatory subunit associated protein 1-like 1 [RefSeq_peptide;Acc:NP_060244]	metabolic process
1.69345	up	GC-rich sequence DNA-binding factor (GCF) (Transcription factor 9) (TCF-9). [Uniprot/SWISSPROT;Acc:P16383]	regulation of transcription
			regulation of transcription, DNA-dependent
1.69658	down	CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase (EC 2.4.99.-) (Beta-galactoside alpha-2,3-sialyltransferase) (Alpha 2,3-sialyltransferase IV) (Alpha 2,3-ST) (Gal-NAc6S) (STZ) (SIAT4-C) (ST3Gal III) (SAT-3) (ST-4). [Uniprot/SWISSPROT;Acc:Q11206]	protein amino acid glycosylation
1.69856	up	Myosin light chain kinase 2, skeletal/cardiac muscle (EC 2.7.11.18) (MLCK2). [Uniprot/SWISSPROT;Acc:Q9H1R3]	neuromuscular synaptic transmission
			protein amino acid phosphorylation
1.72628	down	Coiled-coil domain-containing protein 108. [Uniprot/SWISSPROT;Acc:Q6ZU64]	DNA repair
1.72656		protein phosphatase 1, regulatory subunit 15B [RefSeq_peptide;Acc:NP_116222]	ER overload response
			response to hydrogen peroxide
			response to oxidative stress
1.73211		Antigen KI-67. [Uniprot/SWISSPROT;Acc:P46013]	cell cycle
			cell proliferation
			meiosis
			regulation of progression through cell cycle
1.73291	up	BTB/POZ domain-containing protein KCTD8. [Uniprot/SWISSPROT;Acc:Q6ZWB6]	potassium ion transport
1.75026		Claudin-11 (Oligodendrocyte-specific protein). [Uniprot/SWISSPROT;Acc:O75508]	axon ensheathment
			calcium-independent cell-cell adhesion
			cell adhesion
			spermatogenesis
1.75846	down	Cystinosin. [Uniprot/SWISSPROT;Acc:O60931]	amino acid metabolic process
			L-cystine transport
			transport
1.76583		leukocyte-derived arginine aminopeptidase [RefSeq_peptide;Acc:NP_071745]	antigen processing and presentation of endogenous peptide antigen via MHC class I
			blood pressure regulation
			proteolysis
1.76994		ADAM 12 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 12) (Meltrin alpha). [Uniprot/SWISSPROT;Acc:O43184]	cell adhesion
			myoblast fusion
			proteolysis
1.78439	up	Chromodomain helicase-DNA-binding protein 4 (EC 3.6.1.-) (ATP- dependent helicase CHD4) (CHD-4) (Mi-2 autoantigen 218 kDa protein) (Mi2-beta). [Uniprot/SWISSPROT;Acc:Q14839]	chromatin assembly or disassembly
			chromatin modification
			chromosome organization and biogenesis (sensu Eukaryota)
			intracellular signaling cascade
			regulation of transcription from RNA polymerase II promoter
			transcription
1.79094		Protein FAM65A. [Uniprot/SWISSPROT;Acc:Q6ZS17]	signal transduction
1.7961		RAS-like, family 11, member A [RefSeq_peptide;Acc:NP_996563]	protein transport
			small GTPase mediated signal transduction
1.80858	down	Rhophilin-1 (GTP-Rho-binding protein 1). [Uniprot/SWISSPROT;Acc:Q8TCX5]	signal transduction
1.81557		Putative DNA helicase INO80 complex homolog 1 (EC 3.6.1.-) (hINO80). [Uniprot/SWISSPROT;Acc:Q9ULG1]	homoiothermy
			response to freezing
1.82311		Fibroblast growth factor 5 precursor (FGF-5) (HBGF-5) (Smag-82). [Uniprot/SWISSPROT;Acc:P12034]	cell proliferation
			cell-cell signaling
			fibroblast growth factor receptor signaling pathway
			glial cell differentiation
			nervous system development
			regulation of progression through cell cycle
1.83496	up	Protein FAN (Factor associated with N-SMase activation) (Factor associated with neutral sphingomyelinase activation). [Uniprot/SWISSPROT;Acc:Q92636]	ceramide metabolic process
			signal transduction
1.83601		coiled-coil domain containing 90A [RefSeq_peptide;Acc:NP_001026883]	G-protein coupled receptor protein signaling pathway

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.