MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Class	Ratio	Regulation	Gene Ontology	description	Gene	Minimum Ratio	Accession	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 501 to 550 of 2667 in total

Class  : biological process

Ratio	Regulation	Gene Ontology	description
1.60668	up	response to mechanical stimulus	Transient receptor potential cation channel subfamily V member 4 (TrpV4) (osm-9-like TRP channel 4) (OTRPC4) (Vanilloid receptor-like channel 2) (Vanilloid receptor-like protein 2) (VRL-2) (Vanilloid receptor-related osmotically-activated channel) (VR-OAC [Uniprot/SWISSPROT;Acc:Q9HBA0]
1.60746	down	chromatin assembly or disassembly	Chromodomain-helicase-DNA-binding protein 6 (EC 3.6.1.-) (ATP- dependent helicase CHD6) (CHD-6) (Radiation-induced gene B protein). [Uniprot/SWISSPROT;Acc:Q8TD26]
		chromatin remodeling
		nervous system development
		nucleosome assembly
		regulation of transcription, DNA-dependent
		response to antibiotic
		tetracycline transport
		transcription
1.61347		ciliary or flagellar motility	Calmodulin-like protein 5 (Calmodulin-like skin protein). [Uniprot/SWISSPROT;Acc:Q9NZT1]
		epidermis development
		signal transduction
1.61673	up	protein amino acid phosphorylation	Calcium/calmodulin-dependent protein kinase type 1B (EC 2.7.11.17) (CaM kinase IB) (CaM kinase I beta) (CaMKI-beta) (CaM-KI beta) (Pregnancy up-regulated non-ubiquitously expressed CaM kinase). [Uniprot/SWISSPROT;Acc:Q6P2M8]
1.61987		activation of MAPKK activity	Proteinase-activated receptor 1 precursor (PAR-1) (Thrombin receptor) (Coagulation factor II receptor). [Uniprot/SWISSPROT;Acc:P25116]
		anatomical structure morphogenesis
		apoptosis
		blood coagulation
		caspase activation
		cell motility
		elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)
		establishment of synaptic specificity at neuromuscular junction
		G-protein coupled receptor protein signaling pathway
		multicellular organismal development
		negative regulation of neuron apoptosis
		positive regulation of calcium ion transport
		positive regulation of cell proliferation
		positive regulation of I-kappaB kinase/NF-kappaB cascade
		positive regulation of smooth muscle contraction
		positive regulation of vasoconstriction
		protein kinase C activation
		regulation of progression through cell cycle
		regulation of sensory perception of pain
		release of sequestered calcium ion into cytosol
		response to wounding
		signal transduction
		STAT protein nuclear translocation
		tyrosine phosphorylation of STAT protein
1.62709		dephosphorylation	Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48) (His domain-containing protein tyrosine phosphatase) (HD-PTP) (Protein tyrosine phosphatase TD14) (PTP-TD14). [Uniprot/SWISSPROT;Acc:Q9H3S7]
		protein amino acid dephosphorylation
1.63639		biological_process	Cysteine-rich hydrophobic domain 2 protein (BrX-like translocated in leukemia). [Uniprot/SWISSPROT;Acc:Q9UKJ5]
1.6384		G-protein coupled receptor protein signaling pathway	Olfactory receptor 6S1. [Uniprot/SWISSPROT;Acc:Q8NH40]
		signal transduction
1.63945		cell cycle	Mitogen-activated protein kinase 4 (EC 2.7.11.24) (Extracellular signal-regulated kinase 4) (ERK-4) (MAP kinase isoform p63) (p63- MAPK). [Uniprot/SWISSPROT;Acc:P31152]
		protein amino acid phosphorylation
1.65422		signal transduction	Uncharacterized protein C9orf117. [Uniprot/SPTREMBL;Acc:Q5JU67]
1.65835	down	selenocysteine incorporation	Selenocysteine-specific elongation factor (Elongation factor sec) (Eukaryotic elongation factor, selenocysteine-tRNA-specific). [Uniprot/SWISSPROT;Acc:P57772]
		translational elongation
1.66123	up	G-protein coupled receptor protein signaling pathway	KRAB-A domain containing 1 (KRBA1), mRNA [RefSeq_dna;Acc:NM_032534]
		regulation of transcription, DNA-dependent
1.66679		protein amino acid ADP-ribosylation	TCDD-inducible poly [ADP-ribose] polymerase (EC 2.4.2.30) (Poly [ADP- ribose] polymerase 7) (PARP-7). [Uniprot/SWISSPROT;Acc:Q7Z3E1]

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.