MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	Class	Gene Ontology	description	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 501 to 550 of 2667 in total

Ratio	Regulation	Class	Gene Ontology	description
1.24114	down	cellular component	myosin complex	Myosin-15 (Myosin heavy chain 15). [Uniprot/SWISSPROT;Acc:Q9Y2K3]
			striated muscle thick filament
		molecular function	actin binding
			ATP binding
			calmodulin binding
			motor activity
			nucleotide binding
1.24359		biological process	exocytosis	Calcium-dependent secretion activator 2 (Calcium-dependent activator protein for secretion 2) (CAPS-2). [Uniprot/SWISSPROT;Acc:Q86UW7]
			protein transport
		cellular component	cell junction
			cytoplasmic vesicle
			membrane
			synapse
		molecular function	calcium ion binding
			lipid binding
1.24361		biological process	metabolic process	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA (EC 3.2.1.113) (Processing alpha-1,2-mannosidase IA) (Alpha-1,2-mannosidase IA) (Mannosidase alpha class 1A member 1) (Man(9)-alpha-mannosidase) (Man9-mannosidase). [Uniprot/SWISSPROT;Acc:P33908]
			protein amino acid glycosylation
		cellular component	endoplasmic reticulum
			ER-Golgi intermediate compartment
			Golgi apparatus
			integral to membrane
			membrane
			membrane fraction
		molecular function	calcium ion binding
			hydrolase activity, acting on glycosyl bonds
			mannosidase activity
			mannosyl-oligosaccharide 1,2-alpha-mannosidase activity
1.24964		biological process	immune response	Atlastin-2 (ADP-ribosylation factor-like protein 6-interacting protein 2). [Uniprot/SWISSPROT;Acc:Q8NHH9]
		cellular component	integral to membrane
			membrane
		molecular function	GTP binding
			GTPase activity
			nucleotide binding
			protein binding
1.25113		biological process	regulation of transcription, DNA-dependent	Zinc finger protein OZF (Only zinc finger protein) (Zinc finger protein 146). [Uniprot/SWISSPROT;Acc:Q15072]
		cellular component	intracellular
			nucleus
		molecular function	DNA binding
			heparin binding
			metal ion binding
			nucleic acid binding
			zinc ion binding
1.25147	up	biological process	cell-cell signaling	T-lymphocyte activation antigen CD86 precursor (Activation B7-2 antigen) (CTLA-4 counter-receptor B7.2) (B70) (FUN-1) (BU63). [Uniprot/SWISSPROT;Acc:P42081]
			immune response
			positive regulation of cell proliferation
			positive regulation of interleukin-2 biosynthetic process
			positive regulation of interleukin-4 biosynthetic process
			positive regulation of lymphotoxin A biosynthetic process
			positive regulation of T-helper 2 cell differentiation
			positive regulation of transcription

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.