Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes


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Gene Ontology Accession Regulation description Ratio Class Minimum Ratio Gene Maximum Ratio
Results: HTML CSV LaTeX Showing element 1 to 50 of 2667 in total
Gene Ontology
Regulation
description
Ratio
Class
1-phosphatidylinositol-3-kinase activity down Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (EC 2.7.1.153) (PI3-kinase p110 subunit gamma) (PtdIns-3- kinase subunit p110) (PI3K) (PI3Kgamma) (p120-PI3K). [Uniprot/SWISSPROT;Acc:P48736] 5.23046 molecular function
2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity up Dehydrogenase/reductase SDR family member 1 (EC 1.1.-.-). [Uniprot/SWISSPROT;Acc:Q96LJ7] 1.25729
2-acylglycerol O-acyltransferase activity Diacylglycerol O-acyltransferase 2 (EC 2.3.1.20) (Diglyceride acyltransferase 2). [Uniprot/SWISSPROT;Acc:Q96PD7] 3.31364
3-chloroallyl aldehyde dehydrogenase activity down Aldehyde dehydrogenase 1A3 (EC 1.2.1.5) (Aldehyde dehydrogenase 6) (Retinaldehyde dehydrogenase 3) (RALDH-3). [Uniprot/SWISSPROT;Acc:P47895] 1.20924
7S RNA binding Protein CWC15 homolog. [Uniprot/SWISSPROT;Acc:Q9P013] 1.25205
acetyltransferase activity Arylamine N-acetyltransferase 1 (EC 2.3.1.5) (Arylamide acetylase 1) (Monomorphic arylamine N-acetyltransferase) (MNAT) (N- acetyltransferase type 1) (NAT-1). [Uniprot/SWISSPROT;Acc:P18440] 3.00923
Arylamine N-acetyltransferase 2 (EC 2.3.1.5) (Arylamide acetylase 2) (Polymorphic arylamine N-acetyltransferase) (PNAT) (N- acetyltransferase type 2) (NAT-2). [Uniprot/SWISSPROT;Acc:P11245] 4.69231
actin binding Myosin-15 (Myosin heavy chain 15). [Uniprot/SWISSPROT;Acc:Q9Y2K3] 1.24114
Myosin-If (Myosin-Ie). [Uniprot/SWISSPROT;Acc:O00160] 1.23668
WAS protein homology region 2 domain containing 1 [RefSeq_peptide;Acc:NP_001073904] 1.54676
up Transgelin-2 (SM22-alpha homolog). [Uniprot/SWISSPROT;Acc:P37802] 1.59177
actin cytoskeleton down WAS protein homology region 2 domain containing 1 [RefSeq_peptide;Acc:NP_001073904] 1.54676 cellular component
activation of MAPKK activity up Proteinase-activated receptor 1 precursor (PAR-1) (Thrombin receptor) (Coagulation factor II receptor). [Uniprot/SWISSPROT;Acc:P25116] 1.61987 biological process
actomyosin structure organization and biogenesis Transgelin-2 (SM22-alpha homolog). [Uniprot/SWISSPROT;Acc:P37802] 1.59177
acyltransferase activity Diacylglycerol O-acyltransferase 2 (EC 2.3.1.20) (Diglyceride acyltransferase 2). [Uniprot/SWISSPROT;Acc:Q96PD7] 3.31364 molecular function
adenohypophysis development Somatoliberin precursor (Growth hormone-releasing factor) (GRF) (Growth hormone-releasing hormone) (GHRH) (Somatocrinin) (Somatorelin) (Sermorelin). [Uniprot/SWISSPROT;Acc:P01286] 1.10867 biological process
adult heart development Chromodomain-helicase-DNA-binding protein 7 (EC 3.6.1.-) (ATP- dependent helicase CHD7) (CHD-7). [Uniprot/SWISSPROT;Acc:Q9P2D1] 1.25808
adult walking behavior
alcohol metabolic process down Aldehyde dehydrogenase 1A3 (EC 1.2.1.5) (Aldehyde dehydrogenase 6) (Retinaldehyde dehydrogenase 3) (RALDH-3). [Uniprot/SWISSPROT;Acc:P47895] 1.20924
Aldehyde dehydrogenase, mitochondrial precursor (EC 1.2.1.3) (ALDH class 2) (ALDHI) (ALDH-E2). [Uniprot/SWISSPROT;Acc:P05091] 4.40797
aldehyde dehydrogenase (NAD) activity molecular function
aldehyde dehydrogenase [NAD(P)+] activity Aldehyde dehydrogenase 1A3 (EC 1.2.1.5) (Aldehyde dehydrogenase 6) (Retinaldehyde dehydrogenase 3) (RALDH-3). [Uniprot/SWISSPROT;Acc:P47895] 1.20924
Aldehyde dehydrogenase, mitochondrial precursor (EC 1.2.1.3) (ALDH class 2) (ALDHI) (ALDH-E2). [Uniprot/SWISSPROT;Acc:P05091] 4.40797
amino acid metabolic process Cystinosin. [Uniprot/SWISSPROT;Acc:O60931] 1.75846 biological process
Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) (Amino acid transporter ATB0+) (Solute carrier family 6 member 14). [Uniprot/SWISSPROT;Acc:Q9UN76] 1.40552
up Cysteine desulfurase, mitochondrial precursor (EC 2.8.1.7). [Uniprot/SWISSPROT;Acc:Q9Y697] 1.19539
amino acid transport down Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) (Amino acid transporter ATB0+) (Solute carrier family 6 member 14). [Uniprot/SWISSPROT;Acc:Q9UN76] 1.40552
amino acid transporter activity molecular function
aminoacyl-tRNA ligase activity Threonyl-tRNA synthetase, mitochondrial precursor (EC 6.1.1.3) (Threonine--tRNA ligase) (ThrRS) (Threonyl-tRNA synthetase-like 1). [Uniprot/SWISSPROT;Acc:Q9BW92] 2.25955
aminopeptidase activity leukocyte-derived arginine aminopeptidase [RefSeq_peptide;Acc:NP_071745] 1.76583
anagen Prostaglandin G/H synthase 2 precursor (EC 1.14.99.1) (Cyclooxygenase- 2) (COX-2) (Prostaglandin-endoperoxide synthase 2) (Prostaglandin H2 synthase 2) (PGH synthase 2) (PGHS-2) (PHS II). [Uniprot/SWISSPROT;Acc:P35354] 1.18096 biological process
anatomical structure development up Homeobox protein SIX4 (Sine oculis homeobox homolog 4). [Uniprot/SWISSPROT;Acc:Q9UIU6] 3.70292
anatomical structure morphogenesis down Homeobox protein Hox-D3 (Hox-4A). [Uniprot/SWISSPROT;Acc:P31249] 1.27461
up Proteinase-activated receptor 1 precursor (PAR-1) (Thrombin receptor) (Coagulation factor II receptor). [Uniprot/SWISSPROT;Acc:P25116] 1.61987
angiogenesis Rho GTPase-activating protein 24 (Rho-type GTPase-activating protein 24) (Filamin-A-associated RhoGAP) (FilGAP) (p73RhoGAP) (RhoGAP of 73 kDa) (RAC1- and CDC42-specific GTPase-activating protein of 72 kDa) (RC-GAP72) (Sarcoma antigen NY-SAR-88). [Uniprot/SWISSPROT;Acc:Q8N264] 1.36997
anion exchanger activity down Anion exchange protein 3 (Neuronal band 3-like protein) (Solute carrier family 4 member 3) (Cardiac/brain band 3-like protein) (CAE3/BAE3). [Uniprot/SWISSPROT;Acc:P48751] 2.88235 molecular function
up Chloride anion exchanger (Protein DRA) (Down-regulated in adenoma) (Solute carrier family 26 member 3). [Uniprot/SWISSPROT;Acc:P40879] 1.31661
anion transport down Anion exchange protein 3 (Neuronal band 3-like protein) (Solute carrier family 4 member 3) (Cardiac/brain band 3-like protein) (CAE3/BAE3). [Uniprot/SWISSPROT;Acc:P48751] 2.88235 biological process
up Chloride anion exchanger (Protein DRA) (Down-regulated in adenoma) (Solute carrier family 26 member 3). [Uniprot/SWISSPROT;Acc:P40879] 1.31661
Zinc finger protein 219. [Uniprot/SWISSPROT;Acc:Q9P2Y4] 1.13007
anterior/posterior pattern formation Cytochrome P450 26A1 (EC 1.14.-.-) (Retinoic acid-metabolizing cytochrome) (P450 retinoic acid-inactivating 1) (P450RAI) (hP450RAI) (Retinoic acid 4-hydroxylase). [Uniprot/SWISSPROT;Acc:O43174] 2.69364
anti-apoptosis CD40 ligand (CD40-L) (Tumor necrosis factor ligand superfamily member 5) (TNF-related activation protein) (TRAP) (T cell antigen Gp39) (CD154 antigen) [Contains: CD40 ligand, membrane form; CD40 ligand, soluble form]. [Uniprot/SWISSPROT;Acc:P29965] 1.98149
antigen processing and presentation of endogenous peptide antigen via MHC class I down leukocyte-derived arginine aminopeptidase [RefSeq_peptide;Acc:NP_071745] 1.76583
antiporter activity Anion exchange protein 3 (Neuronal band 3-like protein) (Solute carrier family 4 member 3) (Cardiac/brain band 3-like protein) (CAE3/BAE3). [Uniprot/SWISSPROT;Acc:P48751] 2.88235 molecular function
up Chloride anion exchanger (Protein DRA) (Down-regulated in adenoma) (Solute carrier family 26 member 3). [Uniprot/SWISSPROT;Acc:P40879] 1.31661
AP-1 adaptor complex down Low density lipoprotein receptor adapter protein 1 (Autosomal recessive hypercholesterolemia protein). [Uniprot/SWISSPROT;Acc:Q5SW96] 1.30207 cellular component
AP-2 adaptor complex
apical junction complex up Poliovirus receptor-related protein 3 precursor (Nectin-3) (CD113 antigen) (CDw113). [Uniprot/SWISSPROT;Acc:Q9NQS3] 1.4628
apical plasma membrane Chloride anion exchanger (Protein DRA) (Down-regulated in adenoma) (Solute carrier family 26 member 3). [Uniprot/SWISSPROT;Acc:P40879] 1.31661
apoptosis down Calsenilin (Kv channel-interacting protein 3) (KChIP3) (A-type potassium channel modulatory protein 3) (DRE-antagonist modulator) (DREAM). [Uniprot/SWISSPROT;Acc:Q9Y2W7] 3.27919 biological process

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- http://analysis.yellowcouch.org/