MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Class	Regulation	Ratio	description	Gene Ontology	Gene	Minimum Ratio	Accession	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 501 to 550 of 2667 in total

Class  : biological process
Regulation  : up

Ratio	description	Gene Ontology
1.21698	Kelch-like protein 34. [Uniprot/SWISSPROT;Acc:Q8N239]	metabolic process
1.21705	T-complex protein 1 subunit beta (TCP-1-beta) (CCT-beta). [Uniprot/SWISSPROT;Acc:P78371]	cellular protein metabolic process
		protein amino acid phosphorylation
		protein folding
		regulation of progression through cell cycle
1.22047	HORMA domain-containing protein 1 (Newborn ovary HORMA protein) (Cancer/testis antigen CT46). [Uniprot/SWISSPROT;Acc:Q86X24]	mitosis
1.22178	Serine/threonine-protein kinase PFTAIRE-1 (EC 2.7.11.22). [Uniprot/SWISSPROT;Acc:O94921]	protein amino acid phosphorylation
1.22502	ATP-binding cassette sub-family A member 3 (ATP-binding cassette transporter 3) (ATP-binding cassette 3) (ABC-C transporter). [Uniprot/SWISSPROT;Acc:Q99758]	response to drug
		transport
1.22528	protein tyrosine phosphatase domain containing 1 protein isoform 2 [RefSeq_peptide;Acc:NP_818931]	dephosphorylation
		protein amino acid dephosphorylation
1.22576	Methyl-CpG-binding domain protein 1 (Methyl-CpG-binding protein MBD1) (Protein containing methyl-CpG-binding domain 1). [Uniprot/SWISSPROT;Acc:Q9UIS9]	negative regulation of transcription
		regulation of transcription, DNA-dependent
		transcription
		transcription from RNA polymerase II promoter
1.22694	Protein FAM73B. [Uniprot/SPTREMBL;Acc:Q7L4E1]	type I hypersensitivity
1.25147	T-lymphocyte activation antigen CD86 precursor (Activation B7-2 antigen) (CTLA-4 counter-receptor B7.2) (B70) (FUN-1) (BU63). [Uniprot/SWISSPROT;Acc:P42081]	cell-cell signaling
		immune response
		positive regulation of cell proliferation
		positive regulation of interleukin-2 biosynthetic process
		positive regulation of interleukin-4 biosynthetic process
		positive regulation of lymphotoxin A biosynthetic process
		positive regulation of T-helper 2 cell differentiation
		positive regulation of transcription
		T cell activation
		T cell proliferation
1.25729	Dehydrogenase/reductase SDR family member 1 (EC 1.1.-.-). [Uniprot/SWISSPROT;Acc:Q96LJ7]	enterobactin biosynthetic process
		metabolic process
1.25808	Chromodomain-helicase-DNA-binding protein 7 (EC 3.6.1.-) (ATP- dependent helicase CHD7) (CHD-7). [Uniprot/SWISSPROT;Acc:Q9P2D1]	adult heart development
		adult walking behavior
		blood vessel development
		camera-type eye development
		chromatin assembly or disassembly
		chromatin modification
		circulation
		embryonic hindlimb morphogenesis
		female genitalia development
		heart morphogenesis
		in utero embryonic development
		inner ear morphogenesis
		locomotory behavior
		nose development
		palate development
		positive regulation of body size
		regulation of transcription, DNA-dependent
		sensory perception of sound
		transcription
1.2734	Neurexin-2-alpha precursor (Neurexin II-alpha). [Uniprot/SWISSPROT;Acc:Q9P2S2]	cell adhesion
		neurotransmitter secretion
		synaptic transmission

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.