MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Regulation	Ratio	Gene Ontology	description	Class	Gene	Minimum Ratio	Maximum Ratio	Accession

Results: HTML CSV LaTeX

Showing element 501 to 550 of 948 in total

Regulation  : up
Class  : biological process

Ratio	Gene Ontology	description
1.21698	metabolic process	Kelch-like protein 34. [Uniprot/SWISSPROT;Acc:Q8N239]
1.21705	cellular protein metabolic process	T-complex protein 1 subunit beta (TCP-1-beta) (CCT-beta). [Uniprot/SWISSPROT;Acc:P78371]
	protein amino acid phosphorylation
	protein folding
	regulation of progression through cell cycle
1.22047	mitosis	HORMA domain-containing protein 1 (Newborn ovary HORMA protein) (Cancer/testis antigen CT46). [Uniprot/SWISSPROT;Acc:Q86X24]
1.22178	protein amino acid phosphorylation	Serine/threonine-protein kinase PFTAIRE-1 (EC 2.7.11.22). [Uniprot/SWISSPROT;Acc:O94921]
1.22502	response to drug	ATP-binding cassette sub-family A member 3 (ATP-binding cassette transporter 3) (ATP-binding cassette 3) (ABC-C transporter). [Uniprot/SWISSPROT;Acc:Q99758]
	transport
1.22528	dephosphorylation	protein tyrosine phosphatase domain containing 1 protein isoform 2 [RefSeq_peptide;Acc:NP_818931]
	protein amino acid dephosphorylation
1.22576	negative regulation of transcription	Methyl-CpG-binding domain protein 1 (Methyl-CpG-binding protein MBD1) (Protein containing methyl-CpG-binding domain 1). [Uniprot/SWISSPROT;Acc:Q9UIS9]
	regulation of transcription, DNA-dependent
	transcription
	transcription from RNA polymerase II promoter
1.22694	type I hypersensitivity	Protein FAM73B. [Uniprot/SPTREMBL;Acc:Q7L4E1]
1.25147	cell-cell signaling	T-lymphocyte activation antigen CD86 precursor (Activation B7-2 antigen) (CTLA-4 counter-receptor B7.2) (B70) (FUN-1) (BU63). [Uniprot/SWISSPROT;Acc:P42081]
	immune response
	positive regulation of cell proliferation
	positive regulation of interleukin-2 biosynthetic process
	positive regulation of interleukin-4 biosynthetic process
	positive regulation of lymphotoxin A biosynthetic process
	positive regulation of T-helper 2 cell differentiation
	positive regulation of transcription
	T cell activation
	T cell proliferation
1.25729	enterobactin biosynthetic process	Dehydrogenase/reductase SDR family member 1 (EC 1.1.-.-). [Uniprot/SWISSPROT;Acc:Q96LJ7]
	metabolic process
1.25808	adult heart development	Chromodomain-helicase-DNA-binding protein 7 (EC 3.6.1.-) (ATP- dependent helicase CHD7) (CHD-7). [Uniprot/SWISSPROT;Acc:Q9P2D1]
	adult walking behavior
	blood vessel development
	camera-type eye development
	chromatin assembly or disassembly
	chromatin modification
	circulation
	embryonic hindlimb morphogenesis
	female genitalia development
	heart morphogenesis
	in utero embryonic development
	inner ear morphogenesis
	locomotory behavior
	nose development
	palate development
	positive regulation of body size
	regulation of transcription, DNA-dependent
	sensory perception of sound
	transcription
1.2734	cell adhesion	Neurexin-2-alpha precursor (Neurexin II-alpha). [Uniprot/SWISSPROT;Acc:Q9P2S2]
	neurotransmitter secretion
	synaptic transmission

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.