MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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description	Ratio	Gene Ontology	Regulation	Class	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 501 to 550 of 1501 in total

Regulation  : up

description	Ratio	Gene Ontology	Class
GTP-binding protein Rhes precursor (Ras homolog enriched in striatum) (Tumor endothelial marker 2). [Uniprot/SWISSPROT;Acc:Q96D21]	3.64872	cellular_component	cellular component
		GTP binding	molecular function
		GTPase activity
		intracellular	cellular component
		intracellular protein transport	biological process
		locomotory behavior
		membrane	cellular component
		nucleocytoplasmic transport	biological process
		nucleotide binding	molecular function
		protein binding
		protein transport	biological process
		signal transduction
		small GTPase mediated signal transduction
GTP-binding protein SAR1a (COPII-associated small GTPase). [Uniprot/SWISSPROT;Acc:Q9NR31]	1.40602	cytoplasm	cellular component
		endoplasmic reticulum
		ER to Golgi vesicle-mediated transport	biological process
		Golgi apparatus	cellular component
		GTP binding	molecular function
		GTPase activity
		intracellular	cellular component
		intracellular protein transport	biological process
		nucleotide binding	molecular function
		small GTPase mediated signal transduction	biological process
Guanylate cyclase soluble subunit beta-2 (EC 4.6.1.2) (GCS-beta-2). [Uniprot/SWISSPROT;Acc:O75343]	1.18489	cGMP biosynthetic process
		cyclic nucleotide biosynthetic process
		cytoplasm	cellular component
		guanylate cyclase activity	molecular function
		heme binding
		intracellular signaling cascade	biological process
		iron ion binding	molecular function
		metal ion binding
		phosphorus-oxygen lyase activity
Hermansky-Pudlak syndrome 3 protein. [Uniprot/SWISSPROT;Acc:Q969F9]	2.2939	cytoplasm	cellular component
		organelle organization and biogenesis	biological process
		pigmentation
Homeobox protein Nkx-2.8 (Homeobox protein NK-2 homolog H). [Uniprot/SWISSPROT;Acc:O15522]	1.30407	axonogenesis
		multicellular organismal development
		nucleus	cellular component
		regulation of transcription, DNA-dependent	biological process
		RNA polymerase II transcription factor activity	molecular function
		sequence-specific DNA binding
		transcription factor activity
		transcription from RNA polymerase II promoter	biological process
Homeobox protein SIX4 (Sine oculis homeobox homolog 4). [Uniprot/SWISSPROT;Acc:Q9UIU6]	3.70292	anatomical structure development
		embryonic skeletal morphogenesis
		homoiothermy
		ice binding	molecular function
		inner ear morphogenesis	biological process
		multicellular organismal development
		myoblast migration

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.