MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Gene Ontology	Regulation	description	Class	Gene	Minimum Ratio	Maximum Ratio	Accession

Results: HTML CSV LaTeX

Showing element 51 to 100 of 948 in total

Class  : biological process

Ratio	Gene Ontology	Regulation	description
1.16823	G1/S transition of mitotic cell cycle	up	S-phase kinase-associated protein 2 (F-box protein Skp2) (Cyclin A/CDK2-associated protein p45) (p45skp2) (F-box/LRR-repeat protein 1). [Uniprot/SWISSPROT;Acc:Q13309]
	regulation of progression through cell cycle
	ubiquitin cycle
1.16921	cell differentiation		Transcription cofactor HES-6 (Hairy and enhancer of split 6) (C- HAIRY1). [Uniprot/SWISSPROT;Acc:Q96HZ4]
	multicellular organismal development
	nervous system development
	regulation of transcription
	regulation of transcription from RNA polymerase II promoter
	regulation of transcription, DNA-dependent
1.17693	biological_process		Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1). [Uniprot/SWISSPROT;Acc:Q9H4M7]
1.17879	inner ear morphogenesis		Potassium voltage-gated channel subfamily KQT member 4 (Voltage-gated potassium channel subunit Kv7.4) (Potassium channel subunit alpha KvLQT4) (KQT-like 4). [Uniprot/SWISSPROT;Acc:P56696]
	ion transport
	potassium ion transport
	sensory perception of sound
1.18096	anagen	down	Prostaglandin G/H synthase 2 precursor (EC 1.14.99.1) (Cyclooxygenase- 2) (COX-2) (Prostaglandin-endoperoxide synthase 2) (Prostaglandin H2 synthase 2) (PGH synthase 2) (PGHS-2) (PHS II). [Uniprot/SWISSPROT;Acc:P35354]
	blood pressure regulation
	cell motility
	cyclooxygenase pathway
	electron transport
	fatty acid biosynthetic process
	negative regulation of cell proliferation
	regulation of inflammatory response
	regulation of progression through cell cycle
	response to oxidative stress
1.18489	cGMP biosynthetic process	up	Guanylate cyclase soluble subunit beta-2 (EC 4.6.1.2) (GCS-beta-2). [Uniprot/SWISSPROT;Acc:O75343]
	cyclic nucleotide biosynthetic process
	intracellular signaling cascade
1.18821	cytokine and chemokine mediated signaling pathway	down	Cytokine receptor common beta chain precursor (GM-CSF/IL-3/IL-5 receptor common beta-chain) (CD131 antigen) (CDw131). [Uniprot/SWISSPROT;Acc:P32927]
	respiratory gaseous exchange
	signal transduction
1.19117	G-protein coupled receptor protein signaling pathway	up	Ras-related GTP-binding protein D (Rag D). [Uniprot/SWISSPROT;Acc:Q9NQL2]
	transport
1.19134	cell-cell signaling	down	Proprotein convertase subtilisin/kexin type 6 precursor (EC 3.4.21.-) (Paired basic amino acid cleaving enzyme 4) (Subtilisin/kexin-like protease PACE4) (Subtilisin-like proprotein convertase 4) (SPC4). [Uniprot/SWISSPROT;Acc:P29122]
	determination of left/right symmetry
	proteolysis
	zygotic determination of anterior/posterior axis, embryo
1.19207	mRNA export from nucleus	up	Nuclear RNA export factor 2 (TAP-like protein 2) (TAPL-2). [Uniprot/SWISSPROT;Acc:Q9GZY0]
	multicellular organismal development
	transport
1.19212	hormone biosynthetic process	down	Thyroglobulin precursor. [Uniprot/SWISSPROT;Acc:P01266]
	signal transduction
	thyroid hormone generation
1.19496	carbohydrate metabolic process	up	Isocitrate dehydrogenase [NADP] cytoplasmic (EC 1.1.1.42) (Cytosolic NADP-isocitrate dehydrogenase) (Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific ICDH) (IDP). [Uniprot/SWISSPROT;Acc:O75874]
	glutathione metabolic process
	glyoxylate cycle
	isocitrate metabolic process
	metabolic process
	response to oxidative stress
	tricarboxylic acid cycle
1.19539	amino acid metabolic process		Cysteine desulfurase, mitochondrial precursor (EC 2.8.1.7). [Uniprot/SWISSPROT;Acc:Q9Y697]

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.