MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Regulation	description	Ratio	Class	Gene Ontology	Gene	Minimum Ratio	Accession	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 490 to 539 of 2667 in total

Regulation  : down

description	Ratio	Class	Gene Ontology
Homeobox protein Hox-D3 (Hox-4A). [Uniprot/SWISSPROT;Acc:P31249]	1.27461	molecular function	galanin receptor activity
			sequence-specific DNA binding
			transcription factor activity
Homeobox protein TGIF2 (5'-TG-3'-interacting factor 2) (TGFB-induced factor 2) (TGF(beta)-induced transcription factor 2). [Uniprot/SWISSPROT;Acc:Q9GZN2]	3.48313	biological process	regulation of transcription, DNA-dependent
		cellular component	nucleus
		molecular function	sequence-specific DNA binding
			transcription factor activity
Insulin-induced gene 1 protein (INSIG-1). [Uniprot/SWISSPROT;Acc:O15503]	1.23845	biological process	cell proliferation
			cholesterol metabolic process
			lipid metabolic process
			metabolic process
			response to sterol depletion
			steroid metabolic process
		cellular component	endoplasmic reticulum
			integral to membrane
			membrane
		molecular function	protein binding
Inter-alpha-trypsin inhibitor heavy chain H2 precursor (ITI heavy chain H2) (Inter-alpha-inhibitor heavy chain 2) (Inter-alpha-trypsin inhibitor complex component II) (Serum-derived hyaluronan-associated protein) (SHAP). [Uniprot/SWISSPROT;Acc:P19823]	2.08208	biological process	hyaluronan metabolic process
		cellular component	extracellular region
		molecular function	serine-type endopeptidase inhibitor activity
Isopentenyl-diphosphate Delta-isomerase 2 (EC 5.3.3.2) (IPP isomerase 2) (Isopentenyl pyrophosphate isomerase 2) (IPPI2). [Uniprot/SWISSPROT;Acc:Q9BXS1]	1.43088	biological process	carotenoid biosynthetic process
			cholesterol biosynthetic process
			isoprenoid biosynthetic process
		cellular component	peroxisome
		molecular function	hydrolase activity
			isomerase activity
			isopentenyl-diphosphate delta-isomerase activity
			magnesium ion binding
Junctophilin-1 (Junctophilin type 1) (JP-1). [Uniprot/SWISSPROT;Acc:Q9HDC5]	3.39764	biological process	biological_process
			muscle development
		cellular component	integral to membrane
			junctional membrane complex
			membrane
			microsome
			sarcoplasmic reticulum
			Z disc
		molecular function	molecular_function
			structural constituent of muscle
Keratin-associated protein 19-2. [Uniprot/SWISSPROT;Acc:Q3LHN2]	1.69153	cellular component	intermediate filament
Ketosamine-3-kinase (EC 2.7.1.-) (Fructosamine-3-kinase-related protein). [Uniprot/SWISSPROT;Acc:Q9HA64]	1.18141	molecular function	kinase activity
			transferase activity
leucine-rich repeat neuronal 6A [RefSeq_peptide;Acc:NP_116197]	2.79087	biological process	defense response
		cellular component	integral to membrane
			membrane
		molecular function	protein binding
Leukocyte antigen CD37 (Tetraspanin-26) (Tspan-26). [Uniprot/SWISSPROT;Acc:P11049]	4.62042	biological process	protein amino acid N-linked glycosylation
			visual perception
		cellular component	integral to membrane
			integral to plasma membrane
			membrane

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.